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Publication FFR-Guided Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Diabetes.(JAMA Cardiology |, 2025-03-12) Takahashi, Kuniaki; Otsuki, Hisao; Zimmermann, Frederik M; Ding, Victoria Y; Engstrøm, Thomas; Hørsted Thyregod, Hans Gustav; Beleslin, Branko; Putnik, Svetozar; Tapp, Luke; Barker, Thomas; Redwood, Simon; Young, Christopher; Bech, G Jan-Willem; Hoohenkerk, Gerard J F; De Bruyne, Bernard; Pijls, Nico H J; Fearon, William FNonePublication Maternal and neonatal outcomes following resuscitative hysterotomy for out of hospital cardiac arrest : a systematic review(Resuscitation, 2024-12-28) Leech, Caroline; Nutbeam, Tim; Chu, Justin; Knight, Marian; Hinshaw, Kim; Appleyard, Tracy-Louise; Cowan, Stephanie; Couper, Keith; Yeung, Joyce; University Hospitals of Coventry and Warwickshire, Warwick Evidence Group, University of Warwick, UK. Electronic address: tarunya.arun@uhcw.nhs.uk. 2Department of Neurology, South Tyneside and Sunderland NHS Foundation Trust, South Shields, UK. 3Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. 4Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Department of Neurosciences, University of Leeds Faculty of Medicine and Health, Leeds, UK. 5Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. 6Neurology Department, Southern General Hospital, Glasgow. 7Darent Valley Hospital, University College London Hospital. 8University Hospitals Birmingham. 9The National Hospital for Neurology and Neurosurgery, Queen Square, London. 10Department of Neurology, Belfast Health and Social Care Trust, Belfast, UK. 11Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh, Edinburgh, UK; Department of Neurology, Forth Valley Royal Hospital, Larbert, UK. 12St George's University Hospitals NHS Foundation Trust. 13The Blizard Institute (Neuroscience, Surgery & Trauma), Queen Mary University of London, The Royal London Hospital, Barts Health NHS Trust. 14Centre for Preventive Neurology, Wolfson Institute of Population Health and Barts Health NHS Trust.; Medical and DentalThe review was registered with PROSPERO (CRD42023445064). Studies included pregnant women with out of hospital cardiac arrest and resuscitative hysterotomy performed (in any setting) during cardiac arrest. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL), from inception to 25th May 2024, restricted to humans. We included randomised controlled trials, observational studies, cases series or case reports. Two reviewers independently assessed study eligibility, extracted study data, and assessed risk of bias using validated tools. Data are summarised in a narrative synthesis.Publication Pregnancies in women with Turner syndrome: a retrospective multicentre UK study(Wiley-Blackwell, 2022-03-22) Cauldwell, M; Steer, P J; Adamson, D; Alexander, C; Allen, L; Bhagra, C; Bolger, A; Bonner, S; Calanchini, M; Carroll, A; Casey, R; Curtis, S; Head, C; English, K; Hudsmith, L; James, R; Joy, E; Keating, N; MacKiliop, L; McAuliffe, F; Morris, R K; Mohan, A; Von Klemperer, K; Kaler, M; Rees, D A; Shetty, A; Siddiqui, F; Simpson, L; Stocker, L; Timmons, P; Vause, S; Turner, H E; St George's Hospital; Chelsea and Westminster Hospital; University Hospitals Coventry and Warwickshire; Edinburgh Royal Infirmary; Cardiff and Vale University Health Board; Addenbrookes Hospital; Glenfield Hospital; Manchester University Foundation Trust; Oxford University Hospitals NHS Foundation Trust; University Hospital Southampton NHS Foundation Trust; University Hospitals Bristol NHS Foundation Trust; Norfolk and Norwich University Hospital; Leeds Teaching Hospitals NHS Trust; University Hospitals Birmingham NHS Foundation Trust; University Hospitals Sussex; University College Dublin; National Maternity Hospital; Birmingham Women's and Children's NHS Foundation Trust; Barts Heart Centre; Royal London Hospital; Cardiff University; Aberdeen Royal Infirmary; Royal Leicester Infirmary; Princess Anne Hospital; Cardiology; Medical and Dental; Hudsmith, Lucy; Adamson, DObjective: To determine the characteristics and outcomes of pregnancy in women with Turner syndrome. Design: Retrospective 20-year cohort study (2000-20). Setting: Sixteen tertiary referral maternity units in the UK. Population or sample: A total of 81 women with Turner syndrome who became pregnant. Methods: Retrospective chart analysis. Main outcome measures: Mode of conception, pregnancy outcomes. Results: We obtained data on 127 pregnancies in 81 women with a Turner phenotype. All non-spontaneous pregnancies (54/127; 42.5%) were by egg donation. Only 9/31 (29%) pregnancies in women with karyotype 45,X were spontaneous, compared with 53/66 (80.3%) pregnancies in women with mosaic karyotype 45,X/46,XX (P < 0.0001). Women with mosaic karyotype 45,X/46,XX were younger at first pregnancy by 5.5-8.5 years compared with other Turner syndrome karyotype groups (P < 0.001), and more likely to have a spontaneous menarche (75.8% versus 50% or less, P = 0.008). There were 17 miscarriages, three terminations of pregnancy, two stillbirths and 105 live births. Two women had aortic dissection (2.5%); both were 45,X karyotype with bicuspid aortic valves and ovum donation pregnancies, one died. Another woman had an aortic root replacement within 6 months of delivery. Ten of 106 (9.4%) births with gestational age data were preterm and 22/96 (22.9%) singleton infants with birthweight/gestational age data weighed less than the tenth centile. The caesarean section rate was 72/107 (67.3%). In only 73/127 (57.4%) pregnancies was there documentation of cardiovascular imaging within the 24 months before conceiving. Conclusions: Pregnancy in women with Turner syndrome is associated with major maternal cardiovascular risks; these women deserve thorough cardiovascular assessment and counselling before assisted or spontaneous pregnancy managed by a specialist team.Publication FOUND Trial: randomised controlled trial study protocol for case finding of obstructive sleep apnoea in primary care using a novel device(BMJ Publishing Group, 2024-07-25) Miller, Michelle A; Yu, Ly-Mee; Ali, Asad; Apenteng, Patricia; Auguste, Peter; Dale, Jeremy; Hope, Kath; Shanyinde, Milensu; Grabey, Jenna; Scott, Emma; Smith, Anne; Cappuccio, Francesco P; Miller MA, Yu LM, Ali A, Apenteng P, Auguste P, Dale J, Hope K, Shanyinde M, Grabey J, Scott E, Smith A, Cappuccio FP; FOUND Trial study group.; Medical and DentalRandomised controlled trial of case finding of OSA in general practice using a novel Medicines and Healthcare products Regulatory Agency-registered device (AcuPebble SA100) compared with usual care with internal feasibility phase. A diverse sample of general practices (approximately 40) from across the West Midlands Clinical Research Network will identify participants from their records. Eligible participants will be aged 50-70 years with body mass index >30 kg/m2 and diabetes (type 1 or 2) and/or hypertension (office blood pressure >145/90 mm Hg or on treatment). They will exclude individuals with known OSA or chronic obstructive pulmonary disease, or those they deem unable to take part. After eligibility screening, consent and baseline assessment, participants will be randomised to either the intervention or control group. Participants in the intervention arm will receive by post the AcuPebble sleep test kit. Those in the control arm will continue with usual care. Follow-up questionnaires will be completed at 6 months. The study is powered (90%) to detect a 5% difference and will require 606 patients in each arm (713 will be recruited to each arm to allow for attrition). Due to the nature of the intervention, participants and GPs will not be blinded to the allocation.Publication When is a mass not a mass? An unusual presentation of prominent crista terminalis(BMJ Publishing Group, 2016-02-15) Salim, Handi; Palit, Amitabh; Maher, Abdul; University Hospital Coventry and Warwickshire; George Eliot Hospital, Nuneaton; Radiology; Cardiology; Medical and Dental; Palit, Amitabh; Maher, Abdul; Salim, HandiThis case report describes a patient in whom echocardiography showed borderline left ventricular hypertrophy and a mass adjacent to the right atrial wall. This naturally caused some concern as the differential diagnoses included that of a right atrial myxoma and further investigations were organised. A subsequent cardiac MRI revealed this thickening to be a prominent crista terminalis. The crista terminalis is a variant of normal anatomical structures within the right atrium, which mimics an atrial mass.Publication Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads.(Springer, 2023-01-06) Perino, Alexander C; Wang, Paul J; Lloyd, Michael; Zanon, Francesco; Fujiu, Katsuhito; Briongos-Figuero, Sem; Sato, Toshiaki; Aksu, Tolga; Jastrzebski, Marek; Sideris, Skevos; Rao, Praveen; Boczar, Krzysztof; Yuan-Ning, Xu; Wu, Michael; Namboodiri, Narayanan; Garcia, Rodrigue; Kataria, Vikas; De Pooter, Jan; Przibille, Oliver; Gehi, Anil K; Cano, Oscar; Katsouras, Grigorios; Cai, Binni; Astheimer, Klaus; Tanawuttiwat, Tanyanan; Datino, Tomas; Rizkallah, Jacques; Alasti, Mohammad; Feld, Gregory; Barrio-Lopez, Maria Teresa; Gilmore, Mark; Conti, Sergio; Yanagisawa, Satoshi; Indik, Julia H; Zou, Jiangang; Saha, Sandeep A; Rodriguez-Munoz, Daniel; Chang, Kuan-Cheng; Lebedev, Dmitry S; Leal, Miguel A; Haeberlin, Andreas; Forno, Alexander R J Dal; Orlov, Michael; Frutos, Manuel; Cabanas-Grandio, Pilar; Lyne, Jonathan; Leyva, Francisco; Tolosana, Jose Maria; Ollitrault, Pierre; Vergara, Pasquale; Balla, Cristina; Devabhaktuni, Subodh R; Forleo, Giovanni; Letsas, Konstantinos P; Verma, Atul; Moak, Jeffrey P; Shelke, Abhijeet B; Curila, Karol; Cronin, Edmond M; Futyma, Piotr; Wan, Elaine Y; Lazzerini, Pietro Enea; Bisbal, Felipe; Casella, Michela; Turitto, Gioia; Rosenthal, Lawrence; Bunch, T Jared; Baszko, Artur; Clementy, Nicolas; Cha, Yong-Mei; Chen, Huang-Chung; Galand, Vincent; Schaller, Robert; Jarman, Julian W E; Harada, Masahide; Wei, Yong; Kusano, Kengo; Schmidt, Constanze; Hurtado, Marco Antonio Arguello; Naksuk, Niyada; Hoshiyama, Tadashi; Kancharla, Krishna; Iida, Yoji; Mizobuchi, Mashiro; Morin, Daniel P; Cay, Serkan; Paglino, Gabriele; Dahme, Tillman; Agarwal, Sharad; Vijayaraman, Pugazhendhi; Sharma, Parikshit S; Osman, Faizel; Medicine; Medical and Dental; Osman, FaizelAdoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.Publication AF Cryoablation is an effective day case treatment: The United Kingdom PolarX versus AFA experience(Oxford University Press, 2023-09-21) Honarbakhsh, Shohreh; Martin, Claire A; Mesquita, Joao; Herlekar, Rahul; Till, Richard; Srinivasan, Neil T; Duncan, Edward; Leong, Fong; Dulai, Rajdip; Veasey, Rick; Paisey, John; Ramgopal, Balasubramanian; Das, Moloy; Ahmed, Wissam; Sahu, Jonathan; Earley, Mark J; Finlay, Malcolm C; Schilling, Richard J; Hunter, Ross J; Panikker, SandeepBackground: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation for atrial fibrillation (AF). There are limited data on the PolarX Cryoballoon.Publication Cost-effectiveness of high-intensity interval training (HIIT) versus moderate intensity steady-state (MISS) training in UK cardiac rehabilitation.(Elsevier, 2023-09-18) Albustami, M; Hartfiel, N; Charles, J M; Powell, R; Begg, B; Birkett, S T; Nichols, S; Ennis, S; Hee, S W; Banerjee, P; Ingle, L; Shave, R; Edwards, R T; McGregor, Gordon; Clinical Support Services; Medicine; Allied Health Professional; McGregor, GordonObjective: To perform a cost-effectiveness analysis of high-intensity interval training (HIIT) compared to moderate intensity steady-state (MISS) training in people with coronary artery disease (CAD) attending cardiac rehabilitation (CR).Publication Clinical outcomes of non-COVID-19 orthopaedic patients admitted during the COVID-19 pandemic: a multi-centre interrupted time series analysis across hospitals in six different countries(BMJ Publishing Group, 2023-09-04) Hoogervorst, Lotje Anna; Stijnen, Pieter; Albini, Marco; Janda, Nina; Stewardson, Andrew J; Patel, Kiran; Nelissen, Rob G H H; Marang-van de Mheen, Perla; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands. 2Department of Biomedical Data Sciences & Medical Decision Making, Leiden University Medical Centre, Leiden, Netherlands. 3Department of Management Information and Reporting, Universitaire Ziekenhuizen Leuven, Leuven, Belgium. 4Department of Quality Monitoring, Humanitas Group, Rozzano, Italy. 5Global Health Data@Work, London, UK. 6Department of Infectious Diseases, Alfred Hospital, Melbourne, Victoria, Australia. 7Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK. 8Department of Biomedical Data Sciences & Medical Decision Making, Leiden University Medical Centre, Leiden, Netherlands p.j.marang-van_de_mheen@lumc.nl.; Medicine; Medical and Dental; Patel, KiranObjectives: To assess across seven hospitals from six different countries the extent to which the COVID-19 pandemic affected the volumes of orthopaedic hospital admissions and patient outcomes for non-COVID-19 patients admitted for orthopaedic care.Publication Co-creation of a complex, multicomponent rehabilitation intervention and feasibility trial protocol for the PostUraL tachycardia Syndrome Exercise (PULSE) study.(BMC, 2023-08-15) Pearce, Gemma; Holliday, Nikki; Sandhu, Harbinder; Eftekhari, Helen; Bruce, Julie; Timms, Emma; Ablett, Laura; Kavi, Lesley; Simmonds, Jane; Evans, Rebecca; Magee, Paul; Powell, Richard; Keogh, Shane; McGregor, Gordon; Clinical Support Services; Core Services; Allied Health Professional; Nursing and Midwifery Registered; McGregor, Gordon; Eftekhari, Helen; Bruce, Julie; Powell, RichardBackground: There is a dearth of research to support the treatment of people with postural tachycardia syndrome (PoTS). Despite expert consensus suggesting exercise is recommended for this patient group, there are no randomised control trials examining this rigorously. The aim was to co-create a feasibility trial protocol and a rehabilitation intervention for people living with PoTS.Publication Direct current cardioversion in pregnancy: a multicentre study.(Wiley, 2023-04-11) Cauldwell, M; Adamson, D; Bhatia, K; Bhagra, C; Bolger, A; Everett, T; Fox, C; Girling, J; Head, C; English, K; Hudsmith, L; James, R; Johnson, M; MacKiliop, L; McAuliffe, F M; Mariappa, G; Orchard, E; O'Brien, M; Siddiqui, F; Simpson, L; Simpson, M; Timmons, P; Vause, S; Wander, G; Walker, N; Steer, P J; Cardiology; Medical and Dental; Hudsmith, Lucy; Adamson, DawnObjective: Direct current cardioversion (DCCV) in pregnancy is rarely required and typically only documented in single case reports or case series. A recent UK confidential enquiry reported on several maternal deaths where appropriate DCCV appeared to have been withheld. Design: Retrospective cohort study. Setting: Seventeen UK and Ireland specialist maternity centres. Sample: Twenty-seven pregnant women requiring DCCV in pregnancy. Main outcome measures: Maternal and fetal outcomes following DCCV. Results: Twenty-seven women had a total of 29 DCCVs in pregnancy. Of these, 19 (70%) initial presentations were to Emergency Departments and eight (30%) to maternity settings. There were no maternal deaths. Seventeen of the women (63%) had a prior history of heart disease. Median gestation at DCCV was 28 weeks, median gestation at delivery was 35 weeks, with a live birth in all cases. The abnormal heart rhythms documented at the first cardioversion were atrial fibrillation in 12/27 (44%) cases, atrial flutter in 8/27 (30%), supraventricular tachycardia in 5/27 (19%) and atrial tachycardia in 2/27 (7%). Fetal monitoring was undertaken following DCCV on 14/29 (48%) occasions (10 of 19 (53%) at ≥26 weeks) and on 2/29 (7%) occasions, urgent delivery was required post DCCV. Conclusions: Direct current cardioversion in pregnancy is rarely required but should be undertaken when clinically indicated according to standard algorithms to optimise maternal wellbeing. Once the woman is stable post DCCV, gestation-relevant fetal monitoring should be undertaken. Maternity units should develop multidisciplinary processes to ensure pregnant women receive the same standard of care as their non-pregnant counterparts.Publication Feasibility of novel unshielded portable magnetocardiography: Insights from the prospective multicenter MAGNETO-SCD trial(Elsevier, 2023-03) Lachlan, Thomas; He, Hejie; Miller, Adam; Chandan, Nakul; Siddiqui, Shoaib; Beadle, Roger; Wilson, David; Petkar, Sanjiv; Randeva, Harpal; Osman, Faizel; He, Hejie; Lachlan, Thomas; University Hospitals Coventry and Warwickshire NHS Trust; University of Warwick; University of Leeds; George Eliot Hospital NHS Trust; South Warwickshire University NHS Foundation Trust; Worcester Royal Hospital; Royal Wolverhampton NHS Trust; Cardiology; Medicine; Medical and Dental; Beadle, Roger; He, Hejie; Lachlan, Thomas; Chandan, Nakul; Randeva, HarpalA research letter communicating insights into the feasibility of novel unshielded portable magnetocardiography from the prospective multicenter MAGNETO-SCD trial.