Immune Thrombocytopenia coexisting with Celiac Disease and liver dysfunction : a case report of multifactorial complications
Mughal, Hafiz Muhammad Faizan Khan, Muhammad J Shaikh, Abdul Rehman Khalil
Mughal, Hafiz Muhammad Faizan
Khan, Muhammad J
Shaikh, Abdul Rehman Khalil
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Affiliation
Khawaja Muhammad Safdar Medical College; Sandwell and West Birmingham NHS Trust; Liaquat University of Medical and Health Sciences
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Publication date
2025-08-19
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Abstract
Celiac disease (CD) is a chronic disorder that influences the immune system and is also associated with abnormalities in blood and liver functions. Reports have indicated the presence of immune thrombocytopenia (ITP) and liver diseases in CD, individually, but the simultaneous occurrence of both is rare and therefore difficult to diagnose. Here, we described the case of a 49-year-old woman who had thrombocytopenia and elevated liver enzymes, but showed no gastrointestinal symptoms. However, a complete assessment led to the simultaneous diagnosis of CD, ITP, and autoimmune hepatitis. Treatment with a gluten-free diet and immunosuppressive therapy helped in both restoring the platelet counts and normalizing liver enzymes. The case illustrated that recognizing unusual symptoms in CD is important and it requires the involvement of several experts if immune comorbidities are found.
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Mughal HMF, Khan MJ, Shaikh ARK. Immune Thrombocytopenia Coexisting With Celiac Disease and Liver Dysfunction: A Case Report of Multifactorial Complications. Cureus. 2025 Aug 19;17(8):e90503. doi: 10.7759/cureus.90503
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Article