The impact of outpatient vs inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion - the OPTIMUM randomized clinical trial.
Sivakumar, Parthipan Fitzgerald, Deirdre B Ip, Hugh Rao, Deepak West, Alex Noorzad, Farinaz Wallace, Deirdre Haris, Mohamed Prudon, Benjamin Hettiarachchi, Gihan
Sivakumar, Parthipan
Fitzgerald, Deirdre B
Ip, Hugh
Rao, Deepak
West, Alex
Noorzad, Farinaz
Wallace, Deirdre
Haris, Mohamed
Prudon, Benjamin
Hettiarachchi, Gihan
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2023-11-23
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Abstract
Of participants randomly assigned to IPC (n=70) and chest drain (n=72), primary outcome data were available in 58 and 56 patients, respectively. Global health status improved in both groups at day 30 compared to baseline: IPC (mean difference 13.11 p=0.001) and chest drain (mean difference 10.11 p=0.001). However, there was no significant between-group difference at day 30 (mean inter-group difference in baseline-adjusted global health status of 2.06 ([95% CI -5.86 to 9.99]; p=0.61), day 60 or day 90. No significant differences were identified between groups in breathlessness and chest pain scores. All chest drain arm patients were admitted (median length of stay 4 days); 7 in the IPC arm required intervention-related hospitalization.
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Sivakumar P, Fitzgerald DB, Ip H, Rao D, West A, Noorzad F, Wallace D, Haris M, Prudon B, Hettiarachchi G, Jayaram D, Goldring J, Maskell N, Holme J, Sharma N, Ismail I, Kadwani O, Simpson S, Read CA, Sun X, Douiri A, Lee YG, Ahmed L. The impact of outpatient vs inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion - the OPTIMUM randomized clinical trial. Eur Respir J. 2023 Nov 23:2201215. doi: 10.1183/13993003.01215-2022. Epub ahead of print. PMID: 37996243.
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Article