Mycophenolate versus methotrexate in non-infectious ocular inflammatory disease : a systematic review and meta-analysis
Karam, Mohammad Alsaif, Abdulmalik Al-Naseem, Abdulrahman Hayre, Amrit Al Jabbouri, Abdurrahman Aldubaikhi, Ahmed Kahlar, Narvair Al-Mutairi, Salem
Karam, Mohammad
Alsaif, Abdulmalik
Al-Naseem, Abdulrahman
Hayre, Amrit
Al Jabbouri, Abdurrahman
Aldubaikhi, Ahmed
Kahlar, Narvair
Al-Mutairi, Salem
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Affiliation
University of Leeds; Farwaniya Hospital; Walsall Healthcare NHS Trust; University of Manchester; Whittington Health NHS Trust; St James's University Hospital; King Saud Bin Abdulaziz University for Health Sciences; Sandwell and West Birmingham NHS Trust; Ministry of Health of Kuwait; Kuwait Institute of Medical Specialities (KIMS)
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Publication date
2022-04
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Abstract
Purpose: To compare the outcomes of mycophenolate mofetil (MMF) versus methotrexate (MTX) in non-infectious ocular inflammatory disease (NIOID). Methods: The study was performed as per the PRISMA Guidelines. A search identified all studies comparing MMF versus MTX in NIOID. Treatment result and side effects were primary outcomes. Results: Four studies enrolling 905 patients were identified. There was no significant difference between MMF and MTX groups in overall treatment success (OR = 0.97, P = .96), treatment failure (OR = 0.86, P = .85). MTX showed a significantly improved effect in cases involving posterior uveitis and panuveitis (OR = 0.41, P = .003). In addition, MTX was associated with a faster median time to treatment success and had less side effects when compared to MTX, however this was not significant. For secondary outcomes, no significant difference was found in visual acuity and resolution of macular oedema. Conclusion: MMF is comparable to MTX in the treatment of NIOID.
Citation
Karam, M., Alsaif, A., Al-Naseem, A., Hayre, A., Al Jabbouri, A., Aldubaikhi, A., Kahlar, N., & Al-Mutairi, S. (2023). Mycophenolate versus Methotrexate in Non-infectious Ocular Inflammatory Disease: A Systematic Review and Meta-Analysis. Ocular immunology and inflammation, 31(3), 613–620.
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Article