One Step Nucleic Acid amplification testing for CK19 : single copy number >5,000 copies/μL vs Total Tumour Load of 15,000 copies/μL
Atherton, Gavin Tafazal, Habib Amin, Verda Dakka, Mahmoud Khan, Mashuk Harries, Simon Jones, Lucie Clarke, Dayalan
Atherton, Gavin
Tafazal, Habib
Amin, Verda
Dakka, Mahmoud
Khan, Mashuk
Harries, Simon
Jones, Lucie
Clarke, Dayalan
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Affiliation
South Warwickshire University NHS Foundation Trust
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Publication date
2015-06
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Abstract
Background: The diagnostic criteria for OSNA proposes cut-off values of >5000 copies/μL of CK 19 mRNA as macro-metastases. Practice in our centre is to perform axillary node clearance (ANC) on patients with a copy number of >5000 in any node. A recent study has suggested an alternative method using the total copy number of all sentinel nodes (Total Tumour Load) with a cut-off of 15,000 copies/μL.
Citation
Atherton G, Tafazal H, Amin V, Dakka M, Khan M, Harries S, Jones L, Clarke D. P165. One Step Nucleic Acid amplification testing for CK19: Single copy number >5,000 copies/μL vs Total Tumour Load of 15,000 copies/μL. Eur J Surg Oncol. 2015 Jun;41(6):S72. doi: 10.1016/j.ejso.2015.03.203.
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Conference Output