Identification and response to a putatively hypervirulent, carbapenem-resistant ST395 hospital outbreak in the UK
Garvey, Mark I Moran, Robert A Sanches Ferreira, Ana D Harker, Jean Wilkes, Sarah Holden, Elisabeth McNally, Alan
Garvey, Mark I
Moran, Robert A
Sanches Ferreira, Ana D
Harker, Jean
Wilkes, Sarah
Holden, Elisabeth
McNally, Alan
Affiliation
University of Birmingham; University Hospitals Birmingham NHS Foundation Trust
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Publication date
2025-11-20
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Abstract
Here, we describe a putatively hypervirulent, carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) outbreak. Nanopore sequencing guided the infection prevention and control (IPC) responses during the outbreak. Twelve patients were identified as either being colonized and/or having clinical infections with the putative hv-CRKP, with an all-cause mortality within 6 months of 36%. Multiple IPC responses were put in place, with enhanced cleaning of the environment being the key intervention to halt the outbreak. All isolates were ST395 and contained at least one bla NDM carbapenemase gene, along with a variable array of other antimicrobial resistance and virulence genes, due to a rapidly evolving set of plasmids.
Citation
Garvey MI, Moran RA, Sanches Ferreira AD, Harker J, Wilkes S, Holden E, McNally A. Identification and response to a putatively hypervirulent, carbapenem-resistant Klebsiella pneumoniae ST395 hospital outbreak in the UK. Microb Genom. 2025 Nov;11(11). doi: 10.1099/mgen.0.001571.
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Article