Real-world evidence for secukinumab in UK patients with psoriatic arthritis or radiographic axial spondyloarthritis : interim 2-year analysis from SERENA
Gullick, Nicola
Gullick, Nicola
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Affiliation
University Hospitals Coventry and Warwickshire NHS Trust
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Publication date
2023-08-21
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Abstract
The safety set comprised 189 patients (PsA, n = 81; r-axSpA, n = 108), and the target population set comprised 183 patients (PsA, n = 78; r-axSpA, n = 105). In the safety set, 107 patients (45 of 81 with PsA and 62 of 108 with r-axSpA) had previously received a biologic agent. Retention rates were similar between patients with PsA and r-axSpA after 1 year (PsA 91.0%, 95% CI: 84.0, 98.0; r-axSpA 89.2%, 95% CI: 82.7, 95.7) and 2 years (PsA 77.6%, 95% CI: 67.6, 87.7; r-axSpA 76.2%, 95% CI: 67.4, 85.0) of observation. Overall, 17.5% of patients (33 of 189) experienced at least one treatment-related adverse event, and 12.7% of patients (24 of 189) discontinued secukinumab because of adverse events.
Citation
Rheumatol Adv Pract
. 2023 Aug 21;7(3):rkad055
Type
Article