Regression of intestinal failure-associated liver disease by alteration of lipid emulsion regime in home parenteral nutrition: A case report.
Mohamed, Shahd A Gamage, Manoji Parker, Richard Brown, Rachel M Cooper, Sheldon C
Mohamed, Shahd A
Gamage, Manoji
Parker, Richard
Brown, Rachel M
Cooper, Sheldon C
Affiliation
University Hospitals Birmingham NHS Foundation Trust; University of Birmingham
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Publication date
2025-07-31
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Abstract
Up to 65% of patients receiving parenteral nutrition (PN) have intestinal failure-associated liver disease (IFALD) and ~25% will have fibrosis on biopsy. First-generation lipid injectable emulsions (ILEs) are considered a greater risk factor for IFALD compared with newer formulations. We describe a case report of an adult patient with intestinal failure receiving PN who had improvement of liver function tests (LFTs) and regression of fibrosis on liver biopsy following a switch from 100% soybean oil (SO) ILE to SO, medium-chain triglyceride, olive oil, and fish oil ILE. This supports the only other existing adult case report in the literature to date, which showed histological improvement but no improvements in LFTs.
Citation
Mohamed SA, Gamage M, Parker R, Brown RM, Cooper SC. Regression of intestinal failure-associated liver disease by alteration of lipid emulsion regime in home parenteral nutrition: A case report. Nutr Clin Pract. 2025 Oct;40(5):1212-1218. doi: 10.1002/ncp.70005. Epub 2025 Jul 31.
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Article