An expert consensus statement on biomarkers of ageing for use in intervention studies.
Perri, Giorgia French, Chloe Agostinis-Sobrinho, César Anand, Atul Antarianto, Radiana Dhewayani Arai, Yasumichi Baur, Joseph A Cauli, Omar Clivaz-Duc, Morgane Colloca, Giuseppe
Perri, Giorgia
French, Chloe
Agostinis-Sobrinho, César
Anand, Atul
Antarianto, Radiana Dhewayani
Arai, Yasumichi
Baur, Joseph A
Cauli, Omar
Clivaz-Duc, Morgane
Colloca, Giuseppe
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Affiliation
Newcastle University; University of Manchester; Sport Physical Activity and Health Research and Innovation Center; Klaipeda University; University of Edinburgh; Universitas Indonesia; Keio University School of Medicine; University of Pennsylvania; University of Valencia; CareConnex; Fondazione Policlinico Universitario Agostino Gemelli; Max Plank Institute for Biology of Ageing; University of Cologne; Stavanger University Hospital; King's College London; University College London; University of Connecticut Medical School; University of Warwick; Northumbria Healthcare NHS Foundation Trust; University of Greenwich; University of Westminster; Wake Forest University School of Medicine; National Institute of Health Baltimore; University Hospital Coventry and Warwickshire NHS Trust; University of Birmingham; University Hospitals Birmingham NHS Foundation Trust; Texas A&M University; World Public Health Nutrition Association; Humanity Inc; National Hellenic Research Foundation; University of Liverpool; University of Wisconsin-Madison; Northumbria University; University of Graz; National University of Singapore; National University Health System Singapore; Edith Cowan University; Lobachevsky State University of Nizhny Novgorod; National Research Medical University Moscow; University of Glasgow; McMaster University; Manchester Metropolitan University Institute of Sport; University of Strathclyde; University of A Coruna; Charite University Berlin; Deakin University; Monash University; Rovira i Virgili University; Institute of Health Carlos III; University of Jyvaskyla; Wellbeing Services County of Central Finland; University of Auckland; Trent University; German Institute of Human Nutrition Potsdam-Rehbrücke; Liverpool Hope University; University of East Anglia; Aberystwyth University; Chinese Academy of Sciences; University of Nicosia
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Publication date
2024-12-21
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Abstract
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.
Citation
Perri G, French C, Agostinis-Sobrinho C, Anand A, Antarianto RD, Arai Y, Baur JA, Cauli O, Clivaz-Duc M, Colloca G, Demetriades C, de Lucia C, Di Gessa G, Diniz BS, Dotchin CL, Eaglestone G, Elliott BT, Espeland MA, Ferrucci L, Fisher J, Grammatopoulos DK, Hardiany NS, Hassan-Smith Z, Hastings WJ, Jain S, Joshi PK, Katsila T, Kemp GJ, Khaiyat OA, Lamming DW, Gallegos JL, Madeo F, Maier AB, Martin-Ruiz C, Martins IJ, Mathers JC, Mattin LR, Merchant RA, Moskalev A, Neytchev O, Ni Lochlainn M, Owen CM, Phillips SM, Pratt J, Prokopidis K, Rattray NJW, Rúa-Alonso M, Schomburg L, Scott D, Shyam S, Sillanpää E, Tan MMC, Teh R, Tobin SW, Vila-Chã CJ, Vorluni L, Weber D, Welch A, Wilson D, Wilson T, Zhao T, Philippou E, Korolchuk VI, Shannon OM. An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies. J Gerontol A Biol Sci Med Sci. 2025 Apr 7;80(5):glae297. doi: 10.1093/gerona/glae297.
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Article