COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: a clinical review.
Galgut, Oliver Ashford, Fiona Deeks, Alexandra Ghataure, Andeep Islam, Mimia Sambhi, Tanvir Ker, Yiu Wayn Duncan, Christopher J A de Silva, Thushan I Hopkins, Susan
Galgut, Oliver
Ashford, Fiona
Deeks, Alexandra
Ghataure, Andeep
Islam, Mimia
Sambhi, Tanvir
Ker, Yiu Wayn
Duncan, Christopher J A
de Silva, Thushan I
Hopkins, Susan
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2024-08-05
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Abstract
Participants included were predominantly female and working age. Median time to infection was 51 days. Reported vaccine effectiveness against infection, symptomatic infection, and infection requiring hospitalisation were between 5 and 100 %, 34 and 100 %, and 65 and 100 % (respectively). No vaccinated HCW deaths were recorded in any study. Pooled estimates of protection against infection, symptomatic infection, and hospitalisation were, respectively, 84.7 % (95 % CI 72.6-91.5 %, p < 0.0001), 86.0 % (95 % CI 67.2 %-94.0 %; p < 0.0001), and 96.1 % (95 % CI 90.4 %-98.4 %). Waning protection against infection was reported by four studies, although protection against hospitalisation for severe infection persists for at least 6 months post vaccination.
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Galgut O, Ashford F, Deeks A, Ghataure A, Islam M, Sambhi T, Ker YW, Duncan CJA, de Silva TI, Hopkins S, Hall V, Klenerman P, Dunachie S, Richter A. COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review. Vaccine X. 2024 Aug 5;20:100546. doi: 10.1016/j.jvacx.2024.100546.
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