Contour improvements in skin graft reconstruction of nasal defects
McNiven, Neil David Butler, Jemma Anari, Shahram
McNiven, Neil David
Butler, Jemma
Anari, Shahram
Affiliation
University Hospitals Birmingham NHS Foundation Trust; Worcestershire Acute Hospitals NHS Trust
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Publication date
2025-12-17
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Abstract
Objectives: This study aimed to describe a one-stage technique for nasal skin defect reconstruction using an oxidised regenerated cellulose/collagen matrix (Promogran™) to enhance contour and graft survival.
Methods: Following excision of a skin lesion, Promogran™ is cut to size, placed in the wound bed to restore contour and provide bulk, saturated with blood and covered with a full-thickness skin graft.
Results: The technique improves cosmesis and enables graft survival over avascular structures, including exposed bone and cartilage. Promogran™ exerts wound-healing effects such as matrix metalloprotease inhibition, regulation of growth factors and cytokines, free-radical scavenging and fibroblast proliferation.
Conclusion: This simple, one-stage approach offers an alternative to complex or multistage reconstruction for patients unsuitable for, or preferring to avoid, more invasive procedures.
Citation
McNiven ND, Butler J, Anari S. Contour improvements in skin graft reconstruction of nasal defects. J Laryngol Otol. 2025 Dec 17:1-5. doi: 10.1017/S0022215125104040. Epub ahead of print.
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Article