Exacerbations of lung disease in Alpha-1 antitrypsin deficiency.
Smith, Daniel J Ellis, Paul R Turner, Alice M
Smith, Daniel J
Ellis, Paul R
Turner, Alice M
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2021-01
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Alpha-1 antitrypsin deficiency (AATD) is an important risk factor for development of chronic obstructive pulmonary disease (COPD). Patients with AATD classically develop a different pattern of lung disease from those with usual COPD, decline faster and exhibit a range of differences in pathogenesis, all of which may be relevant to phenotype and/or impact of exacerbations. There are a number of definitions of exacerbation, with the main features being worsening of symptoms over at least 2 days, which may be associated with a change in treatment. In this article we review the literature surrounding exacerbations in AATD, focusing, in particular, on ways in which they may differ from such events in usual COPD, and the potential impact on clinical management.
Citation
Smith DJ, Ellis PR, Turner AM. Exacerbations of Lung Disease in Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2021 Jan;8(1):162–76. doi: 10.15326/jcopdf.2020.0173
Type
Article