Refractory autoimmune hepatitis in children: considerations for assessment and management
Valamparampil, Joseph Brown, Rachel M McKiernan, Patrick
Valamparampil, Joseph
Brown, Rachel M
McKiernan, Patrick
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2025-12-27
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Abstract
Refractory autoimmune hepatitis (AIH) is defined as intolerance of or unresponsiveness to standard immunosuppression and occurs in 10%-20% of children with AIH. Lack of response or slower than expected response to induction of remission with steroids, despite good compliance, might be the first clue to refractory AIH. Refractoriness to treatment is associated with an 11.7 times higher risk for liver transplantation or death due to liver disease. The first and foremost consideration for the management is to assess compliance with treatment. It is then important to re-evaluate the diagnosis, assess alternative aetiologies which can mimic the clinical, serological, and histological features of AIH, and address the presence of extra-hepatic co-morbidities. It is important to consider the specific clinical situations, previous therapy, and prior adverse effects before deciding on the most appropriate treatment regimen in refractory AIH. Consideration also should be given to compliance with previous therapy, need for drug level monitoring, growth potential, available formulations, route of administration of medication, and children's and families' preferences before deciding on the therapy. Treatment should be decided and monitored only in specialized hepatology centers.
Citation
Phillips R, Ma YT, Hanif W, Shah T, Sivakumar S. Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma. J Clin Transl Hepatol. 2025 Dec 28;13(12):1060-1066. doi: 10.14218/JCTH.2025.00303. Epub 2025 Oct 22
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Journal Article