Network dynamics and therapeutic aspects of mRNA and protein markers with the recurrence sites of pancreatic cancer.
Acharjee, Animesh Okyere, Daniella Nath, Dipanwita Nagar, Shruti Gkoutos, Georgios V
Acharjee, Animesh
Okyere, Daniella
Nath, Dipanwita
Nagar, Shruti
Gkoutos, Georgios V
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2024-05-17
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that typically manifests late patient presentation and poor outcomes. Furthermore, PDAC recurrence is a common challenge. Distinct patterns of PDAC recurrence have been associated with differential activation of immune pathway-related genes and specific inflammatory responses in their tumour microenvironment. However, the molecular associations between and within cellular components that underpin PDAC recurrence require further development, especially from a multi-omics integration perspective. In this study, we identified stable molecular associations across multiple PDAC recurrences and utilised integrative analytics to identify stable and novel associations via simultaneous feature selection. Spatial transcriptome and proteome datasets were used to perform univariate analysis, Spearman partial correlation analysis, and univariate analyses by Machine Learning methods, including regularised canonical correlation analysis and sparse partial least squares. Furthermore, networks were constructed for reported and new stable associations. Our findings revealed gene and protein associations across multiple PDAC recurrence groups, which can provide a better understanding of the multi-layer disease mechanisms that contribute to PDAC recurrence. These findings may help to provide novel association targets for clinical studies for constructing precision medicine and personalised surveillance tools for patients with PDAC recurrence.
Keywords: Canonical correlation analysis; Multi-omics; PDAC; Translational research.
Citation
Acharjee A, Okyere D, Nath D, Nagar S, Gkoutos GV. Network dynamics and therapeutic aspects of mRNA and protein markers with the recurrence sites of pancreatic cancer. Heliyon. 2024 May 17;10(10):e31437. doi: 10.1016/j.heliyon.2024.e31437. PMID: 38803850; PMCID: PMC11128524.
Type
Article