Maternal B12 deficiency during pregnancy dysregulates fatty acid metabolism and induces inflammation in human adipose tissue
Samavat, Jinous
Samavat, Jinous
Citations
Altmetric:
Affiliation
inous Samavat # 1, Joseph Boachie # 1 2, Philip G McTernan 3 4, Mark Christian 1 3, Ponnusamy Saravanan 1 5 6, Antonysunil Adaikala - Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK. 2Department of Medical Laboratory Technology, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. 3Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8 NS, UK. 4De Montfort University, The Newarke, Leicester, LE1 9BH, UK. 5Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital, Nuneaton, Warwickshire, CV10 7DJ, UK. 6Centre for Global Health, Warwick Medical School, University of Warwick, Coventry, UK. 7Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK. adaikala.antonysunil@ntu.ac.uk. 8Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8 NS, UK. adaikala.antonysunil@ntu.ac.uk. #Contributed equally.koteswari 7 8
Other Contributors
Publication date
2025-04-23
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Background: Adipose tissue (AT) responds to excess calorie intake; however, the deficit in micronutrients accompanied by the modern lifestyle is often overlooked. Micronutrient deficiency in pregnancy, particularly vitamin B12 (B12), is commonly associated with higher adiposity, dyslipidemia, and type 2 diabetes (T2D). Studies have demonstrated that dyslipidemia can trigger pro-inflammatory status. However, the release of the pro-inflammatory factors in a tissue-specific micronutrient deficient environment is unexplored. Therefore, we investigated the role of B12 deficiency on lipid metabolism and inflammatory mediators in both in vitro and ex vivo models including human pre-adipocytes, primary adipocytes, mature human white AT (WAT), and its association with metabolic risk.
Citation
Samavat J, Boachie J, McTernan PG, Christian M, Saravanan P, Adaikalakoteswari A. Maternal B12 deficiency during pregnancy dysregulates fatty acid metabolism and induces inflammation in human adipose tissue. BMC Med. 2025 Apr 23;23(1):232. doi: 10.1186/s12916-025-04056-4. PMID: 40264186; PMCID: PMC12016209.
Type
Article