Higher risk of short term COVID-19 vaccine adverse events in myositis patients with autoimmune comorbidities: results from the COVAD study.
Dey, Mrinalini R, Naveen Nikiphorou, Elena Sen, Parikshit Saha, Sreoshy Lilleker, James B Agarwal, Vishwesh Kardes, Sinan Day, Jessica Milchert, Marcin
Dey, Mrinalini
R, Naveen
Nikiphorou, Elena
Sen, Parikshit
Saha, Sreoshy
Lilleker, James B
Agarwal, Vishwesh
Kardes, Sinan
Day, Jessica
Milchert, Marcin
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Affiliation
University of Liverpool; Countess of Chester Hospital NHS Foundation Trust; Sanjay Gandhi Postgraduate Institute of Medical Sciences; Sandwell and West Birmingham NHS Trust
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Publication date
2023-05
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Abstract
Vaccination against coronavirus disease 2 (COVID-19) is known to reduce adverse infection outcomes in the general population. However, most COVID-19 vaccination studies have excluded immunosuppressed individuals and those with systemic autoimmune diseases (SAIDs), including idiopathic inflammatory myopathies (IIMs), leading to a lack of safety data for this patient group.
Studies of self-reported adverse events (AEs) following vaccination against COVID-19 have yielded conflicting results, with either higher or comparable adverse events in IIMs versus healthy controls (HCs) [1, 2]. This could potentially be explained by the effect of coexistent comorbidities on AEs in these patients, especially comorbid autoimmune conditions, an area that remains under-studied.
Citation
Dey, M., R, N., Nikiphorou, E., Sen, P., Saha, S., Lilleker, J. B., Agarwal, V., Kardes, S., Day, J., Milchert, M., Joshi, M., Gheita, T., Salim, B., Velikova, T., Gracia-Ramos, A. E., Parodis, I., Selva O'Callaghan, A., Kim, M., Chatterjee, T., Tan, A. L., … COVAD Study Group (2023). Higher risk of short term COVID-19 vaccine adverse events in myositis patients with autoimmune comorbidities: results from the COVAD study. Rheumatology (Oxford, England), 62(5), e147–e152. https://doi.org/10.1093/rheumatology/keac603
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Article