Bone marrow necrosis and fat embolism syndrome in sickle cell disease during COVID-19 infection treated successfully with sequential red cell and plasma exchange
Rizvi, Syed ; Khakwani, Muhammad ; Pancham, Shivan ; Tsitsikas, Dimitris ; Rudzki, Zbigniew ; Hassan-Smith, Ghaniah ; Bowen, Michael ; Wright, Christine ; Park, Daniel
Rizvi, Syed
Khakwani, Muhammad
Pancham, Shivan
Tsitsikas, Dimitris
Rudzki, Zbigniew
Hassan-Smith, Ghaniah
Bowen, Michael
Wright, Christine
Park, Daniel
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Affiliation
University Hospitals Birmingham NHS Foundation Trust; Sandwell and West Birmingham Hospitals NHS Trust; Homerton University Hospital NHS Foundation Trust
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Publication date
2022-12-15
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Abstract
Fat embolism syndrome (FES) is a rare life-threatening condition that is particularly seen in milder forms of sickle cell disease (SCD). Widespread systemic fat emboli are generated in the context of extensive bone marrow necrosis. Multi-organ failure with a high morbidity and mortality may quickly develop. Infection with Parvovirus B19 is a common precipitant. Here, the authors report the case of a 35-year-old Afro-Caribbean man with HbSC disease who presented with FES having tested positive for SARS-COV-2. He rapidly became critically ill and required admission to the intensive care unit for organ support. He was treated with red cell exchange and plasma exchange and made a good recovery to leave hospital at week 7.
Citation
EJHaem. 2022 Dec 15;4(1):207-10. doi: 10.1002/jha2.621. Online ahead of print.
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Article