A non-inferiority clinical trial comparing probiotics and oral corticosteroids for the management of acute exacerbation of atopic dermatitis patients
Gamal, Nahla A. Shoaib, Mohammed A. Farag, Azza G. Stark, Richard
Gamal, Nahla A.
Shoaib, Mohammed A.
Farag, Azza G.
Stark, Richard
Affiliation
Menoufia University, Shebin El-Kom, Egypt; South Warwickshire University NHS Foundation Trust; University of Warwick
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Publication date
2024-04-06
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Collections
Research Projects
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Abstract
A prospective controlled pilot study on the feasibility of utilization of a probiotic mixture for management of acute exacerbation of atopic dermatitis (AD). Patients were allocated to either standard of care (SOC) therapy with tapering dose of steroids or a probiotic mixture over 3 weeks. After the 3-week intervention, patients on steroids achieved significantly higher clinical response rates and significantly deeper response as measured by the change in SCORAD score. No gut microbiome changes could be appreciated in either group after the treatment period. We could conclude that probiotics cannot replace SOC therapy for the management of acute exacerbation of AD.
Citation
Gamal NA, Shoaib MA, Farag AG, Stark R, Tso S. A non-inferiority clinical trial comparing probiotics and oral corticosteroids for the management of acute exacerbation of atopic dermatitis patients. Skin Health Dis. 2024 Apr 6;4(3):e373. doi: 10.1002/ski2.373.
Type
Article