There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia
Williamson, Joseph Black, Louisa Black, Anna Koduri, Gouri Kelly, Clive
Williamson, Joseph
Black, Louisa
Black, Anna
Koduri, Gouri
Kelly, Clive
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Affiliation
Sheffield University; Walsall Healthcare NHS Trust; St Thomas' Hospital; Southend Hospitals; University of Newcastle Upon Tyne
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Publication date
2022-02
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Collections
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Abstract
Introduction: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both.
Methods: This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders.
Results: The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this.
Discussion: We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.
Citation
Williamson J, Black L, Black A, Koduri G, Kelly C. There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia. Ir J Med Sci. 2022 Feb;191(1):1-5.
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Article