Atrial fibrillation in UK South Asian hospitalized ischemic stroke patients : the BRAINS study
Aurelius, Taylor Ken-Dror, Gie Sharma, Sapna D Amlani, Sageet Gunathilagan, Gunaratnam Cohen, David L Rajkumar, Chakravarthi Maguire, Stuart Balogun, Ibrahim
Aurelius, Taylor
Ken-Dror, Gie
Sharma, Sapna D
Amlani, Sageet
Gunathilagan, Gunaratnam
Cohen, David L
Rajkumar, Chakravarthi
Maguire, Stuart
Balogun, Ibrahim
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Affiliation
University of London; Royal London Hospital; Queen Elizabeth the Queen Mother Hospital; Northwick Park Hospital; Brighton and Sussex University Hospitals NHS Trust & University of Sussex; Bradford Teaching Hospital; City Hospital Birmingham; William Harvey Hospital; Hillingdon Hospital; Luton and Dunstable Hospital; Newham University Hospital; Croydon University Hospital; West Middlesex University; Leeds General Infirmary; New Cross Hospital; Walsall Healthcare NHS Trust; Queen's Park Hospital Royal; Birmingham Heartlands Hospital; Airedale General Hospital; Ashford & St Peter's NHS Foundation Trust; Imperial College Healthcare NHS Trust
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Publication date
2023-02-07
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Abstract
Introduction: South Asian diaspora comprise one of the largest ethnic minority groups in the world yet data about atrial fibrillation (AF) in this demographic is understudied. Our aim is to identify differences in AF prevalence and treatment between South Asians and white British stroke patients.
Method: The UK arm of a prospective ongoing large international repository on stroke was analysed. Ethnic differences in AF prevalence and management in those with ischemic stroke were analysed.
Results: Of the 3515 individuals recruited with ischemic stroke, 1482 (men: 972, women: 510) were South Asian and 2033 (men:1141, women:892) of white British ethnicity. AF was present in 462 white British and 193 South Asians stroke patients, with South Asians displaying a lower prevalence of AF (South Asians: 13.0% vs white British 22.7%, P<0.001). Despite adjustment for traditional AF risk factors, South Asians had a significantly lower OR of AF compared to white British stroke patients (OR: 0.40, 95%CI: 0.33:0.49, P<0.001). Among confirmed AF cases, 31.8% of South Asians and 41.4% of white British were untreated at admission (P = 0.02). Antiplatelet treatment was significantly higher among South Asians at both admission (South Asian: 47.4% vs. white British: 29.9%, P<0.001) and discharge (South Asian: 49.5% vs. white British: 34.7%, P = 0.001), although anticoagulation treatment was similar across both ethnic groups at admission (South Asian: 28.5% vs white British: 28.1%, P = 0.93), and discharge (South Asian: 45.1% vs white British: 43.1%, P = 0.64).
Conclusion: Stroke patients of South Asian descent are at significantly lower risk of AF but more likely to be on antiplatelet treatment compared to their white British counterparts.
Citation
Aurelius T, Ken-Dror G, Sharma SD, Amlani S, Gunathilagan G, Cohen DL, Rajkumar C, Maguire S, Ispoglou S, Balogun I, Parry A, Sekaran L, Syed H, Lawrence E, Singh R, Hassan A, Wharton C, Javaid K, Goorah N, Carr P, Abdus Sami E, Sharma P. Atrial fibrillation in UK South Asian hospitalized ischemic stroke patients: The BRAINS study. PLoS One. 2023 Feb 7;18(2):e0281014.
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Article