COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis
Mohan, Mohapradeep Perry, Benjamin Ian Saravanan, Ponnusamy Singh, Swaran Preet
Mohan, Mohapradeep
Perry, Benjamin Ian
Singh, Swaran Preet
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Affiliation
University of Warwick; University of Cambridge; George Eliot Hospital; Coventry and Warwickshire Partnership Trust
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Publication date
2021-05-17
Subject
Research Projects
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Abstract
As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.
Citation
Mohan M, Perry BI, Saravanan P, Singh SP. COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis. Front Psychiatry. 2021 May 17;12:666067. doi: 10.3389/fpsyt.2021.666067. PMID: 34079487; PMCID: PMC8166317.
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Article