PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia
Stanulović, Vesna S Binhassan, Sarah Jaber, Budoor A Alazmi, Shimaa Saleman, Fatma M B Potluri, Sandeep Pratt, Guy Ludwig, Christian Ward, Douglas G Hoogenkamp, Maarten
Stanulović, Vesna S
Binhassan, Sarah
Jaber, Budoor A
Alazmi, Shimaa
Saleman, Fatma M B
Potluri, Sandeep
Pratt, Guy
Ludwig, Christian
Ward, Douglas G
Hoogenkamp, Maarten
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Publication date
2025-07-10
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Abstract
The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex regulates transcription from the onset of hematopoietic development and during differentiation. Chromosomal rearrangements involving LMO2 and TAL1 are causative for T-cell lymphoblastic leukemia (TALL). We have identified Plant Homeodomain (PHD)-like Finger 6 (PHF6) as a new LMO2 interacting factor. Somatic mutations in PHF6 have been found to occur in several types of leukemia. We show that PHF6 interacts with LMO2 as a part of the TAL1, GATA2, LDB1 complex in T-ALL and binds to the DNA. These findings show that PHF6 associates with the TAL1/LMO2/LDB1/GATA2 complex and regulates genes that have a major role in blood development, such as SPI1 (PU.1).
Citation
Stanulović VS, Binhassan S, Jaber BA, Alazmi S, Saleman FMB, Potluri S, Pratt G, Ludwig C, Ward DG, Hoogenkamp M. PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia. Haematologica. 2025 Jul 10. doi: 10.3324/haematol.2024.287124. Epub ahead of print.
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Journal Article