Transcatheter versus surgical closure of atrial septal defects: a systematic review and meta-analysis of clinical outcomes.
Chambault, Aimee-Louise Olsen, Kathryn Brown, Louise J Mellor, Sophie L Sorathia, Nilofer Thomas, Arthur E Kothari, Neel Harky, Amer
Chambault, Aimee-Louise
Olsen, Kathryn
Brown, Louise J
Mellor, Sophie L
Sorathia, Nilofer
Thomas, Arthur E
Kothari, Neel
Harky, Amer
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Affiliation
University of Birmingham; North Cumbria Integrated Care NHS Foundation Trust; University of London; Sandwell West Birmingham NHS Trust
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Publication date
2021-11-25
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Abstract
Background: Atrial septal defects are a common form of CHD and dependent on the size and nature of atrial septal defects, closure may be warranted. The paper aims to compare outcomes of transcatheter versus surgical repair of atrial septal defects.
Methods: A comprehensive electronic literature search was conducted. Primary studies were included if they compared both closure techniques. Primary outcomes included procedural success, mortality, and reintervention rate. Secondary outcomes included residual defect and mean hospital stay.
Results: A total of 33 studies were included in meta-analysis. Mean total hospital stay was significantly shorter in the transcatheter cohort across both the adult (95% confidence interval, mean difference -4.05 (-4.78, -3.32) p < 0.00001) and paediatric populations (95% confidence interval, mean difference -4.78 (-5.97, -3.60) p < 0.00001). There were significantly fewer complications in the transcatheter group across both the adult (odds ratio 0.45, 95% confidence interval, [0.28, 0.72], p < 0.00001) and paediatric cohorts (odds ratio 0.26, 95% confidence interval, [0.14, 0.49], p < 0.00001). No significant difference in overall mortality was found between transcatheter versus surgical closure across the two groups, adult (odds ratio 0.76, 95% confidence interval, [0.40, 1.45], p = 0.41), paediatrics (odds ratio 0.62, 95% confidence interval, [0.21, 1.83], p = 0.39).
Conclusion: Both transcatheter and surgical approaches are safe and effective techniques for atrial septal defect closure. Our study has demonstrated the benefits of transcatheter closure in terms of lower complication rates and mean hospital stay. However, surgery still has a place for more complex closure and, as we have demonstrated, shows no difference in mortality.
Citation
Chambault AL, Olsen K, Brown LJ, Mellor SL, Sorathia N, Thomas AE, Kothari N, Harky A. Transcatheter versus surgical closure of atrial septal defects: a systematic review and meta-analysis of clinical outcomes. Cardiol Young. 2022 Jan;32(1):1-9. doi: 10.1017/S1047951121004583.
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Article