Efficacy and timing of adjunctive therapy in the anti-VEGF treatment regimen for macular oedema in retinal vein occlusion : 12-month real-world result
Lip, P. L. Cikatricis, P. Sarmad, A. Damato, E. M. Chavan, R. Mitra, A. Yang, Y. Mushtaq, B.
Lip, P. L.
Cikatricis, P.
Sarmad, A.
Damato, E. M.
Chavan, R.
Mitra, A.
Yang, Y.
Mushtaq, B.
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Affiliation
Sandwell and West Birmingham NHS Trust; Addenbrooke's Hospital, Cambridge; South Warwickshire University NHS Foundation Trust; The Royal Wolverhampton NHS Trust; Aston University, Birmingham
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Publication date
2018
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Abstract
Purpose
Various combination treatment regimens have been tried to improve the short-term efficacy of intravitreal monotherapy for the treatment of macular oedema (MO) secondary to retinal vein occlusion (RVO). Our study introduces the RandOL protocol (Ranibizumab and Ozurdex with Laser photocoagulation) of initial anti-VEGF therapy, controlling recurrent non-ischaemic MO with an intravitreal steroid and applying laser therapy to non-perfused retina. We describe our 12-month follow-up experience on timing for adjunctive therapy and real-world effectiveness and safety data.
Methods
A retrospective analysis was carried out on 66 consecutive treatment-naive RVO patients with MO who received our RandOL treatment regimen. Baseline visual acuity (VA) and central retinal thickness (CRT) were compared with 12-month result.
Results
At 12 months, 77% had significant VA improvement, 52% had ≥3-line improvement, and 15% were worse. Significant improvements in CRT were observed in 97% (baseline median CRT=531 μm (IQR 435-622) reduced to 245 μm (IQR 221-351, P<0.001) at 12 months); 76% achieved a dry fovea at 1 year. Mean number of total injections required was 5.5 (range 2-11) and 6% required ≥9 injections in 1 year. Although 70% received additional Ozurdex, 82% received ≥1 sessions of laser therapy. The BRVO subgroup achieved better VA and CRT improvement at 1 year, but small numbers limit definitive statistical conclusions.
Conclusions
Our real-world results using a combination treatment protocol for RVO-related MO achieved similar desirable anatomical and visual outcomes as with a single-agent therapy with less intravitreal re-treatment rates at first year. Randomised controlled studies are needed to evaluate the role of laser and the ideal timing of combination therapy.
Citation
Lip PL, Cikatricis P, Sarmad A, Damato EM, Chavan R, Mitra A, Elsherbiny S, Yang Y, Mushtaq B. Efficacy and timing of adjunctive therapy in the anti-VEGF treatment regimen for macular oedema in retinal vein occlusion: 12-month real-world result. Eye (Lond). 2018 Mar;32(3):537-545. doi: 10.1038/eye.2017.230. Epub 2017 Nov 3.
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Article