Steroid refractory autoimmune haemolytic anaemia secondary to sarcoidosis successfully treated with rituximab and mycophenolate mofetil
Green, Sarah Partridge, Erica Idedevbo, Edore Borg, Anton
Green, Sarah
Partridge, Erica
Idedevbo, Edore
Borg, Anton
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South Warwickshire University NHS Foundation Trust
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Publication date
2016-08-02
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Abstract
Autoimmune haemolytic anaemia is not a well-recognised complication of sarcoidosis. We describe the case of a 30-year-old female who presented with acute warm haemolytic anaemia and widespread lymphadenopathy. Sarcoidosis was diagnosed on lymph node biopsy and further investigation. The haemolytic anaemia responded only to a high dose of steroids. Evidence regarding treatment of steroid refractory autoimmune haemolysis secondary to sarcoidosis is lacking. Based on the emergent evidence that both disorders share common immunopathogenic mechanisms involving Th1 and Th17 lymphocytes, our patient was given rituximab and mycophenolate mofetil to successfully suppress the haemolysis and sarcoid activity.
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Green S, Partridge E, Idedevbo E, Borg A. Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil. Case Rep Hematol. 2016;2016:9495761. doi: 10.1155/2016/9495761. Epub 2016 Aug 2.
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