Difficult-to-treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation
Mansur, Adel H ; Marsh, Julie ; Bahron, Ali ; Thomas, Maximillian ; Walters, Gareth
; Busby, John ; Heaney, Liam G ; Krishna, Mamidipudi Thirumala
Mansur, Adel H
Marsh, Julie
Bahron, Ali
Thomas, Maximillian
Busby, John
Heaney, Liam G
Krishna, Mamidipudi Thirumala
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2023-10
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Abstract
A total of 1272 patients [White 1016 (79.9%), EMG 256 (20.1%) EMG] with a median age of 51 years (range 16-97) were included in the analysis. Patients from EMG were more likely (64%) to reside in the worst scale of index of multiple deprivation (IMD) than the White patients (25.5%), p < 0.0001. Positive HDM sensitisation was more prevalent in the EMG than in the White group [142/216 (66%) versus 375/842 (45%), p < 0.0001]. The median HDM ssIgE level was higher in the EMG than in the White group [3.0 KUA/L (IQR 0.06, 11.5) versus 0.1 (0.01, 3.0), p < 0.000001]. The odds ratio for positive sensitisation to HDM conveyed by the EMG status was 2.61 (95%CI, 1.8-3.8), p < 0.0001. Compared to the White group, the EMG had higher median total serum IgE [326 KU/L (115, 971) versus 114 (29.8, 434.8), p < 0.000001], higher blood eosinophil count (0.36 × 109 (0.18, 0.62) versus 0.23 (0.1,0.47), p < 0.000001), were marginally more atopic (79.2% vs. 75.6%, p = 0.098) and were less likely to being on maintenance oral corticosteroids (22% vs. 39.7%, p < 0.0001).
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Mansur AH, Marsh J, Bahron A, Thomas M, Walters G, Busby J, Heaney LG, Krishna MT. Difficult-to-treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation. Clin Transl Allergy. 2023 Oct;13(10):e12303. doi: 10.1002/clt2.12303.
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