Insights into the cellular basis of skin inflammation in systemic autoimmune rheumatic diseases from single-cell technologies
Su, Kevin Y C Roberts, Claudia Heagerty, Adrian H M
Su, Kevin Y C
Roberts, Claudia
Heagerty, Adrian H M
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Affiliation
Sandwell and West Birmingham NHS Trust; University of Birmingham; University Hospitals Birmingham NHS Foundation Trust; University of Birmingham;
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Publication date
2024-07-23
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Abstract
Cutaneous inflammation is a common feature of several systemic autoimmune rheumatic diseases (SARDs) including systemic lupus erythematosus (SLE), undifferentiated connective tissue disease (UCTD), mixed connective tissue disease (MCTD) and dermatomyositis (DM) but is less common in other SARDs such as primary Sjögren's syndrome (pSS). It is important to understand whether the pathophysiological processes underlying skin inflammation are different or shared between SARDs to develop targeted therapies. This review will discuss commonalities and differences between inflammatory skin disease in SARDs focusing on histopathology and describe newer insights obtained from single-cell technologies.
Citation
Su KYC, Roberts C, Heagerty AHM, Reynolds JA. Insights into the cellular basis of skin inflammation in systemic autoimmune rheumatic diseases from single-cell technologies. Clin Exp Rheumatol. 2024 Jul 23. doi: 10.55563/clinexprheumatol/8vvgva
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Article