Management of Nelson's Syndrome.

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dc.contributor.authorFountas, Athanasios
dc.contributor.authorKaravitaki, Niki
dc.contributor.departmentEndocrinologyen_US
dc.contributor.roleMedical and Dentalen_US
dc.contributor.trustauthorKaravitaki, Niki
dc.date.accessioned2023-09-21T15:20:16Z
dc.date.available2023-09-21T15:20:16Z
dc.date.issued2022-11-02
dc.description.abstractNelson's syndrome is a potentially severe condition that may develop in patients with Cushing's disease treated with bilateral adrenalectomy. Its management can be challenging. Pituitary surgery followed or not by radiotherapy offers the most optimal tumour control, whilst pituitary irradiation alone needs to be considered in cases requiring intervention and are poor surgical candidates. Observation is an option for patients with small lesions, not causing mass effects to vital adjacent structures but close follow-up is required for a timely detection of corticotroph tumour progression and for further treatment if required. To date, no medical therapy has been consistently proven to be effective in Nelson's syndrome. Pharmacotherapy, however, should be considered when other management approaches have failed. A subset of patients with Nelson's syndrome may develop further tumour growth after primary treatment, and, in some cases, a truly aggressive tumour behaviour can be demonstrated. In the absence of evidence-based guidance, the management of these cases is individualized and tailored to previously offered treatments. Temozolomide has been used in patients with aggressive Nelson's with no consistent results. Development of tumour-targeted therapeutic agents are an unmet need for the management of aggressive cases of Nelson's syndrome.en_US
dc.identifier.citationFountas A, Karavitaki N. Management of Nelson's Syndrome. Medicina (Kaunas). 2022 Nov 2;58(11):1580. doi: 10.3390/medicina58111580en_US
dc.identifier.doi10.3390/medicina58111580
dc.identifier.eissn1648-9144
dc.identifier.pmid36363537
dc.identifier.urihttp://hdl.handle.net/20.500.14200/2248
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.url1010-660Xen_US
dc.source.countrySwitzerland
dc.source.issue11
dc.source.journaltitleMedicina
dc.source.volume58
dc.subjectBiochemistryen_US
dc.titleManagement of Nelson's Syndrome.en_US
dc.typeArticle
dspace.entity.typePublication
oa.grant.openaccessnaen_US
rioxxterms.versionNAen_US
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