Fibroblast heterogeneity : keystone of tissue homeostasis and pathology in inflammation and ageing
Gauthier, Vincent Kyriazi, Maria Nefla, Meriam Pucino, Valentina Raza, Karim Buckley, Christopher D Alsaleh, Ghada
Gauthier, Vincent
Kyriazi, Maria
Nefla, Meriam
Pucino, Valentina
Raza, Karim
Buckley, Christopher D
Alsaleh, Ghada
Citations
Altmetric:
Affiliation
University of Oxford; University of Birmingham; Newcastle University; Sandwell and West Birmingham NHS Trust
Other Contributors
Publication date
2023-02-28
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts maintain micro-environmental homeostasis and create tissue niches by producing a complex extracellular matrix (ECM) including various structural proteins. Although long considered phenotypically homogenous and functionally identical, the emergence of novel technologies such as single cell transcriptomics has allowed the identification of different phenotypic and cellular states to be attributed to fibroblasts, highlighting their role in tissue regulation and inflammation. Therefore, fibroblasts are now recognised as central actors in many diseases, increasing the need to discover new therapies targeting those cells. Herein, we review the phenotypic heterogeneity and functionality of these cells and their roles in health and disease.
Citation
Gauthier V, Kyriazi M, Nefla M, Pucino V, Raza K, Buckley CD, Alsaleh G. Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing. Front Immunol. 2023 Feb 28;1
Type
Article