Peripheral nailfold capillary microscopic abnormalities in rheumatoid arthritis are associated with arterial stiffness: Results from a cross-sectional study.
Angeloudi E Anyfanti P Dara A Pagkopoulou E Bekiari E Sgouropoulou V Garyfallos A Doumas M Kitas GD Dimitroulas T
Angeloudi E
Anyfanti P
Dara A
Pagkopoulou E
Bekiari E
Sgouropoulou V
Garyfallos A
Doumas M
Kitas GD
Dimitroulas T
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Affiliation
Hippokration Hospital; The Dudley Group NHS Foundation Trust, Dudley; University of Birmingham.
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Publication date
01/11/2023
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Abstract
Vascular injury eventually resulting in the establishment of cardiovascular disease is a serious complication in rheumatoid arthritis (RA). Nailfold videocapillaroscopy (NVC) is a non-invasive imaging modality that enables the quantitative and qualitative assessment of the peripheral microvasculature. Nevertheless, capillaroscopic patterns remain inadequately defined in RA, especially regarding their clinical significance as potential markers of systemic vascular impairment. Consecutive RA patients underwent NVC using a standardized protocol, to assess the following parameters: capillary density, avascular areas, capillary dimensions, microhemorrhages, subpapillary venous plexus, and presence of ramified, bushy, crossed and tortuous capillaries. Carotid-femoral pulse wave velocity (PWV) and pulse pressure were measured as well-acknowledged markers of large artery stiffening. The vast majority of our cohort (n = 44) presented a combination of non-specific and abnormal capillaroscopic parameters. Capillary ramification was associated with both PWV and pulse pressure, even after adjustment for cardiovascular risk factors and systemic inflammation. Our study highlights the high prevalence of a wide range of capillaroscopic deviations from the normal patterns in RA. Furthermore, it provides for the first time evidence of an association between structural disorders of the microcirculation and markers of macrovascular dysfunction, suggesting that NVC might have a role as an index of generalised vascular impairment in RA. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Copyright 2023 Elsevier Inc. All rights reserved.
Citation
Angeloudi E, Anyfanti P, Dara A, Pagkopoulou E, Bekiari E, Sgouropoulou V, Garyfallos A, Doumas M, Kitas GD, Dimitroulas T. Peripheral nailfold capillary microscopic abnormalities in rheumatoid arthritis are associated with arterial stiffness: Results from a cross-sectional study. Microvasc Res. 2023 Nov;150:104576. doi: 10.1016/j.mvr.2023.104576. Epub 2023 Jul 4. PMID: 37414357.
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