Novel impedance-pH parameters in pre-bariatric assessment of patients : a pilot study
Gagliardi, Mario Santonicola, Antonella Palma, Rossella Angrisani, Luigi Iovino, Paola
Gagliardi, Mario
Santonicola, Antonella
Palma, Rossella
Angrisani, Luigi
Iovino, Paola
Citations
Altmetric:
Affiliation
University of Salerno; University of Rome; University of Naples; Sandwell and West Birmingham NHS Trust
Other Contributors
Publication date
2023-01-25
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Novel impedance-pH parameters, Mean Nocturnal Baseline Impedance (MNBI) and Post-Reflux Swallow-Induced Peristaltic Wave (PSPW) index, have been proposed to improve the gastro-esophageal reflux disease (GERD) diagnostic yield. This study aims to determine the integrity of the esophageal epithelial barrier and chemical clearance using these novel parameters and to correlate them with acid exposure time (AET) and acid clearance time (ACT) in obese patients who are candidates for bariatric surgery (BS). Twenty impedance-pHmetry tracings of patients prior to BS were reviewed. Nine (45%) patients with a conclusive diagnosis of GERD had significantly higher ACT, lower MNBI in the distal esophagus and lower PSPW indexes compared to obese patients without GERD. Moreover, 100% of obese patients with GERD had a pathological ACT compared to obese patients without GERD (p = 0.003). However, the percentage of pathological MNBI and PSPW index did not differ between obese patients with and without GERD. The PSPW index and MNBI of the distal channel significantly correlated with ACT and AET. Further studies are needed to assess the role of time-consuming novel parameters in the routine evaluation of morbidly obese patients candidates for BS. The value of acid clearance time is confirmed as a relevant impedance-pH parameter in these patients.
Citation
Gagliardi M, Santonicola A, Palma R, Angrisani L, Trudgill NJ, Iovino P. Novel Impedance-pH Parameters in Pre-Bariatric Assessment of Patients: A Pilot Study. J Clin Med. 2023 Jan 25;12(3):940. doi: 10.3390/jcm12030940
Type
Article