Population-level frequency of fluoroquinolone resistance by whole-genome sequencing drug predictions in Mycobacterium tuberculosis complex isolates in England from 2017-2023
Ferran, Elena Chan, Cathleen Sheikh, Noorann Dedicoat, Martin
Alexander, Eliza Gibertoni-Cruz, Ana Brown, James Robinson, Esther Lipman, Marc
Ferran, Elena
Chan, Cathleen
Sheikh, Noorann
Alexander, Eliza
Gibertoni-Cruz, Ana
Brown, James
Robinson, Esther
Lipman, Marc
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2024-11-13
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Abstract
Fluoroquinolones are an important component of anti-tuberculosis treatment and identifying fluoroquinolone resistance is essential. We present the first survey of fluoroquinolone resistance in England from sequencing of over 16,000 unselected isolates. Fluoroquinolone resistance was 1.4% overall and 23.9% in multidrug-resistant TB. Routine sequencing allows resistance surveillance and should be widely adopted.
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Ferran E, Chan C, Sheikh N, Dedicoat M, Alexander E, Gibertoni-Cruz A, Brown J, Robinson E, Lipman M. Population-level frequency of fluoroquinolone resistance by whole-genome sequencing drug predictions in Mycobacterium tuberculosis complex isolates in England from 2017-2023. Clin Infect Dis. 2024 Nov 13:ciae560. doi: 10.1093/cid/ciae560. Epub ahead of print.
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