Valproate overdose leading to hyperammonaemic encephalopathy
Sharma, Deepak S Gupta, Sandeep Sharma, Priyanka
Sharma, Deepak S
Gupta, Sandeep
Sharma, Priyanka
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Affiliation
Sandwell and West Birmingham NHS Trust; University of Birmingham
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Publication date
2023-07-09
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Abstract
Sodium valproate is a commonly prescribed anticonvulsant medication; however, it can cause uncommon side effects such as hyperammonaemia and encephalopathy. We present the case of a male in his early 50s brought to the emergency department after being found collapsed by his wife, with an empty bottle of sodium valproate tablets. The patient developed hyperammonaemic encephalopathy due to sodium valproate overdose and was treated with supportive care and renal replacement therapy. This case highlights the importance of recognising the potential complications of sodium valproate and its prompt treatment.
Citation
Sharma DS, Gupta S, Sharma P. Valproate overdose leading to hyperammonaemic encephalopathy. BMJ Case Rep. 2023 Jul 9;16(7):e255319. doi: 10.1136/bcr-2023-255319
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Article