Necrobiosis lipoidica in a patient with β-thalassemia major: a case report and review of the literature
Vetsiou, Evangelia Mpouras, Vasileios Nikolaidou, Christina Klonizakis, Philippos Mandala, Evdokia Vamvakis, Kyriakos Psarras, Kyriakos Vlachaki, Efthymia
Vetsiou, Evangelia
Mpouras, Vasileios
Nikolaidou, Christina
Klonizakis, Philippos
Mandala, Evdokia
Vamvakis, Kyriakos
Psarras, Kyriakos
Vlachaki, Efthymia
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Affiliation
South Warwickshire University NHS Foundation Trust; Hippokration Hospital, Aristotle University of Thessaloniki, Greece; Public Health and Social Care, Kavala, Greece
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Publication date
2020-07
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Abstract
Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). The most common skin disorders in patients with β-TM are xerosis, urticaria, pseudoxanthoma, hyperpigmentation, leg ulcers and small-vessel vasculitis. Necrobiosis lipoidica has only been occasionally reported in patients with β-TM. Herein, we present a female with β-TM and NL. Furthermore, a brief review of the literature was performed.
Keywords: ferritin; necrobiosis lipoidica (NL); reactive oxygen species (ROS); β-Thalassemia major (β-TM).
Citation
Vetsiou E, Mpouras V, Nikolaidou C, Klonizakis P, Mandala E, Vamvakis K, Psarras K, Vlachaki E. Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature. Hemoglobin. 2020 May;44(3):221-223. doi: 10.1080/03630269.2020.1783287. Epub 2020 Jul 1.
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