Coronary artery aneurysm post drug-coated balloon angioplasty

Drug-coated balloons have emerged as effective therapy for treating in-stent restenosis and de novo lesions. The animal studies have shown the mechanism of action of paclitaxel-coated balloon in coronary arteries which leads to medial necrosis that may explain the better angiographic remodelling observed with paclitaxel- as compared to sirolimus-coated balloons. However, in some cases, paclitaxel may cause adverse remodelling resulting in coronary artery aneurysm. Here, we report 4 cases of coronary artery aneurysm post paclitaxel-coated balloon angioplasty and discuss its possible mechanism, management, and potential implications for future practice.

Citation

Saboe A, Upadhya C, Finn A, Basavarajaiah S. Coronary Artery Aneurysm Post Drug-Coated Balloon Angioplasty. JACC Case Rep. 2025 Jul 2;30(17):103891. doi: 10.1016/j.jaccas.2025.103891

Type

Report