Identifying research priorities for cognition in CKD: a delphi study
Alexiuk, Jamie Harasemiw, Oksana Vanderlinden, Jessica Verrelli, Davide Tarca, Brett Collister, David Ribeiro, Heitor Corradetti, Bonnie Fowler, Kevin Manfredini, Fabio
Alexiuk, Jamie
Harasemiw, Oksana
Vanderlinden, Jessica
Verrelli, Davide
Tarca, Brett
Collister, David
Ribeiro, Heitor
Corradetti, Bonnie
Fowler, Kevin
Manfredini, Fabio
Affiliation
University of Manitoba; Chronic Disease Innovation Centre; Western University; University of South Australia; University of Alberta; University of Brasilia; Patient Partner Calgary; Voice of the Patient Inc; University of Ferrara; New York University; Langone Health; Johns Hopkins Bloomberg School of Public Health; University of Adelaide; Queen's University Belfast; Amrita Institute of Medical Sciences and Research Centre; Salford Care Organisation; University Hospitals Birmingham NHS Foundation Trust
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Publication date
2025-01-24
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Abstract
Key Points:
Cognitive impairment is prevalent in CKD, affecting quality of life, self-management, and decision-making. It worsens with disease progression.
This Delphi study engaged diverse stakeholders to identify 27 critical research questions on cognitive impairment in CKD for future focus.
Top priorities include preventing cognitive decline, preserving cognition, routine monitoring, and adjusting dialysis treatment to reduce cognitive impairment.
Background: Cognition is a research priority for people living with CKD, but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders.
Methods: A modified Delphi technique with three survey rounds was used. The study sample included three panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through Research Electronic Data Capture. In round 1 (October 2021–May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in round 2 (February–April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the lived experience panel were reranked in round 3 (August–September 2023) and assessed for consensus to identify the final list of priority research questions.
Results: Respondents (n=152) identified 125 and 44 discrete questions after rounds 1 and 2, respectively. The final shortlist included 27 questions in eight categories. The most critical research question identified was “What factors prevent cognitive impairment in people receiving dialysis?” Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment.
Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.
Citation
Alexiuk J, Harasemiw O, Vanderlinden J, Verrelli D, Tarca B, Collister D, Ribeiro H, Corradetti B, Fowler K, Manfredini F, McAdams-DeMarco M, Chu N, Jesudason S, McKeaveney C, Leon SJ, Anandh U, Tollitt J, Thompson S, Dasgupta I, Bohm C; Global Renal Exercise Network. Identifying Research Priorities for Cognition in CKD: A Delphi Study. Kidney360. 2025 May 1;6(5):739-753. doi: 10.34067/KID.0000000708. Epub 2025 Jan 24.
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Article