Fundus topographical distribution patterns of ocular toxoplasmosis.
Hasanreisoglu, Murat Halim, Muhammad Sohail Cakar Ozdal, Pinar Ormaechea, Maria Soledad Kesim, Cem Ozdemir, Huseyin Baran Uludag, Gunay Sredar, Nripun Cankurtaran, Mahmut Liu, Xiaoxuan
Hasanreisoglu, Murat
Halim, Muhammad Sohail
Cakar Ozdal, Pinar
Ormaechea, Maria Soledad
Kesim, Cem
Ozdemir, Huseyin Baran
Uludag, Gunay
Sredar, Nripun
Cankurtaran, Mahmut
Liu, Xiaoxuan
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2023-03-17
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Abstract
Background: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions.
Methods: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed.
Results: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola.
Conclusion: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.
Citation
Hasanreisoglu M, Halim MS, Cakar Ozdal P, Ormaechea MS, Kesim C, Ozdemir HB, Uludag G, Sredar N, Cankurtaran M, Liu X, Denniston AK, Rudzinski MN, Colombero DN, Schlaen BA, Keane PA, Pavesio C, Nguyen QD. Fundus topographical distribution patterns of ocular toxoplasmosis. Br J Ophthalmol. 2024 Mar 20;108(4):530-535. doi: 10.1136/bjo-2022-322747.
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