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Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus: Systematic review and meta-analysis
Shivashri, Chockalingam Deepa, Mohan Ghebremichael-Weldeselassie, Yonas Mohan Anjana, Ranjit Uma, Ram Mohan, Viswanathan Saravanan, Ponnusamy
Shivashri, Chockalingam
Deepa, Mohan
Ghebremichael-Weldeselassie, Yonas
Mohan Anjana, Ranjit
Uma, Ram
Mohan, Viswanathan
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Affiliation
Division of Populations, Evidence, and Technologies of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom; Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, ICMR Center for Advanced Research on Diabetes, Chennai, Tamil Nadu, India; School of Mathematics and Statistics, The Open University, Milton Keynes, United Kingdom; Seethapathy Clinic & Hospital, Chennai, Tamil Nadu, India; Department of Diabetes, Endocrinology, and Metabolism, George Eliot Hospital, Nuneaton, United Kingdom.
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2022-12-12
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Abstract
Background: The burden of Gestational Diabetes Mellitus (GDM) is very high in south Asia (SA) and southeast Asia (SEA). Thus, there is a need to understand the prevalence and risk factors for developing prediabetes and type 2 diabetes mellitus (T2DM) postpartum, in this high-risk population.
Aim: To conduct a systematic review and meta-analysis to estimate the prevalence of prediabetes and T2DM among the women with history of GDM in SA and SEA.
Methods: A comprehensive literature search was performed in the following databases: Medline, EMBASE, Web of Knowledge and CINHAL till December 2021. Studies that had reported greater than six weeks of postpartum follow-up were included. The pooled prevalence of diabetes and prediabetes were estimated by random effects meta-analysis model and I2 statistic was used to assess heterogeneity.
Results: Meta-analysis of 13 studies revealed that the prevalence of prediabetes and T2DM in post-GDM women were 25.9% (95%CI 18.94 to 33.51) and 29.9% (95%CI 17.02 to 44.57) respectively. Women with history of GDM from SA and SEA seem to have higher risk of developing T2DM than women without GDM (RR 13.2, 95%CI 9.52 to 18.29, p<0.001). The subgroup analysis showed a rise in the prevalence of T2DM with increasing duration of follow-up.
Conclusion: The conversion to T2DM and prediabetes is very high among women with history of GDM in SA and SEA. This highlights the need for follow-up of GDM women for early identification of dysglycemia and to plan interventions to prevent/delay the progression to T2DM.
Citation
Shivashri C, Hannah W, Deepa M, Ghebremichael-Weldeselassie Y, Anjana RM, Uma R, Mohan V, Saravanan P. Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus: Systematic review and meta-analysis. PLoS One. 2022 Dec 12;17(12):e0278919. doi: 10.1371/journal.pone.0278919. PMID: 36508451; PMCID: PMC9744276.
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Article