Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges.
Howroyd, Fiona Chacko, Cyril MacDuff, Andrew Gautam, Nandan Pouchet, Brian Tunnicliffe, Bill Weblin, Jonathan Gao-Smith, Fang Ahmed, Zubair Duggal, Niharika A
Howroyd, Fiona
Chacko, Cyril
MacDuff, Andrew
Gautam, Nandan
Pouchet, Brian
Tunnicliffe, Bill
Weblin, Jonathan
Gao-Smith, Fang
Ahmed, Zubair
Duggal, Niharika A
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2024-07-31
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges and pitfalls for the currently available clinical, radiological and microbiological diagnostic armamentarium. Biomarkers and artificial intelligence offer an innovative potential direction for ongoing future research. In this Review, we summarise the pathobiological heterogeneity and diagnostic challenges associated with VAP.
Citation
Howroyd F, Chacko C, MacDuff A, Gautam N, Pouchet B, Tunnicliffe B, Weblin J, Gao-Smith F, Ahmed Z, Duggal NA, Veenith T. Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges. Nat Commun. 2024 Jul 31;15(1):6447. doi: 10.1038/s41467-024-50805-z. PMID: 39085269.
Type
Article
Other
Other