The impact of helicobacter pylori on marginal ulcer formation following gastric bypass: a systematic review and meta-analysis
Rahman, Arifur Mushtaq, Muhammad Nadeem, Faisal Kabir, Syed A
Rahman, Arifur
Mushtaq, Muhammad
Nadeem, Faisal
Kabir, Syed A
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Walsall Healthcare NHS Trust
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Publication date
2025-11-13
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Abstract
Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed bariatric procedures worldwide and is highly effective in improving obesity-related comorbidities; however, marginal ulceration remains a recognised postoperative complication. (HP), a known risk factor for peptic ulcer disease, has an uncertain role in marginal ulcer formation following RYGB. This systematic review and meta-analysis aimed to clarify whether preoperative HP infection increases the risk of marginal ulcer development. A systematic search of PubMed, Embase, and Cochrane databases identified 119 studies, of which seven met inclusion criteria, encompassing 255,899 patients (mean age 42.8 years, mean BMI 47.3 kg/m²). Pooled analysis using a random-effects model demonstrated no significant association between HP infection and marginal ulcer incidence after RYGB (risk ratio = 1.16, 95 % CI 0.23-5.88, p = 0.86), with substantial heterogeneity among studies (I² = 96.4 %, p < 0.0001). These findings suggest that preoperative HP infection does not significantly influence the risk of marginal ulcer formation following RYGB.
Citation
Rahman A, Mushtaq M, Nadeem F, Kabir SA. The Impact of Helicobacter pylori on Marginal Ulcer Formation Following Gastric Bypass: A Systematic Review and Meta-Analysis. Cureus. 2025 Nov 13;17(11):e96787. doi: 10.7759/cureus.96787. PMID: 41393706; PMCID: PMC12701809.
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Article