What are we missing? Data from the gonorrhoea undetected resistance laboratory study (GURLS)

Objectives Increasing ceftriaxone-resistant is of public health concern. A cluster of ceftriaxone-resistant was identified in 2022, which was linked to heterosexuals from the Asia-Pacific region who were studying at UK universities. The possibility of further transmission within and beyond this network was of concern, particularly as not all gonococcal cases have a positive culture for antimicrobial susceptibility testing to be performed. We, therefore, undertook a case finding exercise using an real-time PCR to identify undetected transmission of ceftriaxone-resistant strains. The PCR detects -60.001, which is the most common gonococcal ceftriaxone-resistance mechanism. The aim of this Gonorrhoea Undetected Resistance Laboratory Study was to estimate the prevalence of undetected ceftriaxone-resistant in England. Methods Sexually transmitted infection surveillance data (2017-2021) was combined with university data on student country of origin to identify sexual health services in English university towns with the highest number of gonorrhoea cases among those of Asian ethnicity born in selected countries of the Asia-Pacific region. Residual -positive molecular specimens from women (as a proxy for heterosexual behaviour) aged 18-30 years were sent to the UK Health Security Agency (UKHSA) for testing. Results Between February 2023 and March 2024, 921 specimens meeting the inclusion criteria were received, of which 661 were reconfirmed as . Of these, one was positive on the PCR, indicating ceftriaxone resistance; this specimen came from a previously identified case, therefore no 'undetected' cases were identified. Conclusions This case-finding exercise provided reassurance that ceftriaxone-resistant in England is currently adequately detected through the existing UKHSA-enhanced surveillance activities. The current PCR is a useful tool in the fight to keep gonorrhoea a treatable infection; however, it requires expansion as it does not currently detect all alleles responsible for ceftriaxone resistance.

Citation

Cole MJ, Vickers A, Sun S, Day MJ, Harris R, Burgess Tornaletti L, Thorley K, Ahmed H, Rebec M, O'Connor M, N'Jai-Ndimbalan S, Lord A, Hopkins M, Grant P, Muir P, Sibson K, Mohammed H, Sinka K, Pitt-Kendall R, Fifer H. What are we missing? Data from the Gonorrhoea Undetected Resistance Laboratory Study (GURLS). Sex Transm Infect. 2025 Mar 5:sextrans-2024-056459. doi: 10.1136/sextrans-2024-056459

Type

Article