Non-invasive instrument-based tests for quantifying anterior chamber flare in uveitis: a systematic review
Liu, Xiaoxuan McNally, Thomas W Beese, Sophie Downie, Laura E Solebo, Ameenat L Faes, Livia Husain, Syed Keane, Pearse A Moore, David J Denniston, Alastair K
Liu, Xiaoxuan
McNally, Thomas W
Beese, Sophie
Downie, Laura E
Solebo, Ameenat L
Faes, Livia
Husain, Syed
Keane, Pearse A
Moore, David J
Denniston, Alastair K
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2020-04-07
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures for AC flare.Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability.Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading was 0.40-0.93 and 0.87-0.94 for LFP and protein concentration. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM.Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.
Citation
Liu X, McNally TW, Beese S, Downie LE, Solebo AL, Faes L, Husain S, Keane PA, Moore DJ, Denniston AK. Non-invasive Instrument-Based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review. Ocul Immunol Inflamm. 2021 Jul 4;29(5):982-990. doi: 10.1080/09273948.2019.1709650. Epub 2020 Apr 7
Type
Article