Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)
Lucas, Samuel J E Malein, William L Thomas, Owen D Ashdown, Kimberly M Rue, Carla A Joyce, Kelsey E Newman, Charles Cadigan, Patrick Johnson, Brian Myers, Stephen D
Lucas, Samuel J E
Malein, William L
Thomas, Owen D
Ashdown, Kimberly M
Rue, Carla A
Joyce, Kelsey E
Newman, Charles
Cadigan, Patrick
Johnson, Brian
Myers, Stephen D
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2021-01-07
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Abstract
Twenty participants, paired for age and ACE genotype status, completed a double-blinded, randomised study, where participants took either losartan (100 mg/day) or placebo for 21 days prior to arrival at 5035 m (Whymper Hut, Mt Chimborazo, Ecuador). Participants completed a maximal exercise test on a supine cycle ergometer at sea level (4 weeks prior) and within 48 hours of arrival to 5035 m (10-day ascent). Power output, beat-to-beat BP, oxygen saturation (SpO2) and heart rate (HR) were recorded during exercise, with resting BP collected from daily medicals during ascent. Before and immediately following exercise at 5035 m, extravascular lung water prevalence was assessed with ultrasound (quantified via B-line count).
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BMJ Open Sport Exerc Med . 2021 Jan 7;7(1):e000982
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Article