Impact of social-functioning and sleep on quality of life in chronic inflammatory demyelinating polyneuropathy
Englezou, Christina Nazeer, Kabir K Rajabally, Yusuf A
Englezou, Christina
Nazeer, Kabir K
Rajabally, Yusuf A
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University Hospitals Birmingham; Aston University
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Publication date
2023-10-17
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Abstract
Introduction/aims: The impact of impairment of social functioning and sleep on health-related quality of life (HR-QoL), is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). The value of the Chronic Acquired Polyneuropathy Patient-Reported Index (CAP-PRI) to identify potential social functioning and sleep issues is equally unknown.
Methods: We performed a cross-sectional evaluation of social functioning and sleep using the "Scales for Outcomes in Parkinson's Disease" (SCOPA) in 40 subjects with clinically-stable CIDP through a structured questionnaire. We assessed HR-QoL through the CAP-PRI. Disability was evaluated through the Overall Neuropathy Limitation Score (ONLS).
Results: SCOPA social functioning scores were impaired at least "a little" per averaged item in > 50 % of subjects, and at least "quite a bit" per averaged item in > 20 %. Most affected items were (i) difficulty with work/household/other chores (ii) difficulties with hobbies/sport/leisure activities. SCOPA sleep sub-scores indicated at least "a little concern" for night-time sleep in nearly 50 % of subjects. Abnormal sleep timing was rare. Associations were found between both SCOPA social-functioning and SCOPA sleep scores and the CAP-PRI. Linear regression demonstrated the SCOPA social-functioning score was independently associated with the CAP-PRI. The CAP-PRI showed high association with disability scores, good internal consistency, absence of ceiling effect, absence of significant floor-effect, and good criteria-related as well as construct-related validity.
Discussion: Social functioning and night-time sleep are frequently affected in CIDP and impact on HR-QoL. In contrast to traditional disability scales, the CAP-PRI additionally allows adequately capturing these impairments and may represent an adequate holistic outcome measure.
Citation
Englezou C, Nazeer KK, Rajabally YA. Impact of social-functioning and sleep on quality of life in chronic inflammatory demyelinating polyneuropathy. Clin Neurol Neurosurg. 2023 Nov;234:108017. doi: 10.1016/j.clineuro.2023.108017. Epub 2023 Oct 17. PMID: 37866209.
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Article