Health-related quality of life and cognitive functioning in survivors of oligodendroglioma: an international cross-sectional investigation
Boele, Florien W Frances, Sé M Darlix, Amélie Ducray, Francois Cartalat, Stéphanie Guerdoux, Estelle Tabouret, Emeline Burger, Michael C Rydén, Isabelle Malmstrom, Annika
Boele, Florien W
Frances, Sé M
Darlix, Amélie
Ducray, Francois
Cartalat, Stéphanie
Guerdoux, Estelle
Tabouret, Emeline
Burger, Michael C
Rydén, Isabelle
Malmstrom, Annika
Affiliation
University of Leeds; St James's University Hospital; University of Sheffield; University of Montpellier; Hospices Civils de Lyon; Claude Bernard University; Assistance Publique des Hopitaux de Marseille; Aix-Marseille University; Goethe University Frankfurt; University of Gothenburg; Sahlgrenska University Hospital; Linköping University; University of Rennes; Masaryk University; Masaryk Memorial Cancer Institute; Tubingen University Hospital; University Hospital Cologne; University of Cologne; The Royal Marsden NHS Foundation Trust; University Hospitals Birmingham NHS Foundation Trust; Assistance Publique des Hopitaux de Paris; Sorbonne Université; University of Florence; Azienda Ospedaliero Universitaria Careggi; The Christie NHS Foundation Trust; The Clatterbridge Cancer Centre NHS Foundation Trust; Tayside NHS Trust; Cambridge University Hospitals NHS Foundation Trust; Nottingham University Hospitals NHS Foundation Trust; King's College Hospital; Bordeaux University Hospital Center; Côte d'Azur University; University Hospital Bonn; Jena University Hospital; Friedrich Schiller University Jena; University Hospital Zurich; University of Zurich; Aarhus University Hospital; Odense University Hospital; University of Southern Denmark; Institut de Cancérologie de Strasbourg-Europe (ICANS); Université Clermont Auvergne; Centre Jean Perrin; Centre Francois Baclesse; Hygeia Hospital Athens; Rigshospitalet; Universiteit Amsterdam
Other Contributors
Publication date
2025-07-19
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Background: Patients with oligodendroglioma have a relatively favourable prognosis. The long-term impacts of the tumour itself and its treatment on health-related quality of life (HRQOL) and cognition remain largely unclear. We investigated associations between treatment and functioning of survivors of oligodendroglioma.
Methods: In this cross-sectional observational study, patients with oligodendroglioma, isocitrate dehydrogenase-mutant and 1p/19q-codeleted, diagnosed ≥5 years ago, were recruited. Patients completed patient-reported outcome measures (EORTC QLQ-C30; BN20; MOS Cognitive Complaints Scale) and cognitive tests (HVLT-R, TMT, COWAT). Associations between HRQOL and cognition outcomes, and clinical variables (time since diagnosis; age at diagnosis; progression; tumour location; treatments delivered; time since treatment; current medication;) were explored with regression analyses.
Results: In total, 237 patients M=9.9 years post-diagnosis (sd=4.2, range 5.0-25.8) took part from 33 sites across 9 countries. Clinically relevant levels of impairment were noted in >40% of patients on EORTC QLQ-C30 scales for cognitive functioning (56.1%), emotional functioning (49.8%), fatigue (45.1%), and physical functioning (40.5%). In individuals, cognitive impairment ranged from 17.7% for processing speed to 46.0% for episodic verbal memory (delayed recall). Among other clinical factors such as current use of antiseizure medication or antidepressants, age, disease progression, time since diagnosis and time since treatment, and radiotherapy treatment (ever received) was linked to HRQOL and cognitive functioning outcomes (post-hoc analyses for cumulative radiotherapy dose: not significant).
Conclusions: In oligodendroglioma survivors, HRQOL and cognitive impairment are prevalent even years into follow-up. Supportive care and rehabilitation should be prioritized to mitigate these challenges and improve daily functioning.
Citation
Boele FW, Frances SM, Darlix A, Ducray F, Cartalat S, Guerdoux E, Tabouret E, Burger MC, Rydén I, Malmstrom A, Vauleon E, Kazda T, Renovanz M, Werner JM, Welsh L, Sanghera P, Dehais C, Desideri I, McBain C, Mehta S, Lord H, Jena R, Foweraker K, Ashkan K, Engelhardt J, Bourg V, Herrlinger U, McLean AL, Hertler C, Haldbo-Classen L, Dahlrot RH, Noel G, Durando X, Hrab I, Razis E, Weller M, Muhic A, Klein M. Health-related quality of life and cognitive functioning in survivors of oligodendroglioma: an international cross-sectional investigation. Neuro Oncol. 2025 Jul 19:noaf172. doi: 10.1093/neuonc/noaf172. Epub ahead of print.
Type
Article