Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis.

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dc.contributor.authorGarcía-Azorín, David
dc.contributor.authorDo, Thien Phu
dc.contributor.authorGantenbein, Andreas R
dc.contributor.authorHansen, Jakob Møller
dc.contributor.authorSouza, Marcio Nattan P
dc.contributor.authorObermann, Mark
dc.contributor.authorPohl, Heiko
dc.contributor.authorSchankin, Christoph J
dc.contributor.authorSchytz, Henrik Winther
dc.contributor.authorSinclair, Alexandra
dc.contributor.authorSchoonman, Guus G
dc.contributor.authorKristoffersen, Espen Saxhaug
dc.contributor.departmentDoctorsen_US
dc.contributor.roleMedical and Dentalen_US
dc.contributor.trustauthorSinclair, Alexandra
dc.date.accessioned2024-04-25T13:47:51Z
dc.date.available2024-04-25T13:47:51Z
dc.date.issued2021-09-17
dc.description.abstractBackground: Headache is a frequent symptom following COVID-19 immunization with a typical onset within days post-vaccination. Cases of cerebral venous thrombosis (CVT) have been reported in adenovirus vector-based COVID-19 vaccine recipients. Findings: We reviewed all vaccine related CVT published cases by April 30, 2021. We assessed demographic, clinical variables and the interval between the vaccination and onset of headache. We assessed whether the presence of headache was associated with higher probability of death or intracranial hemorrhage. We identified 77 cases of CVT after COVID-19 vaccination. Patients' age was below 60 years in 74/77 (95.8%) cases and 61/68 (89.7%) were women. Headache was described in 38/77 (49.4%) cases, and in 35/38 (92.1%) was associated with other symptoms. Multiple organ thrombosis was reported in 19/77 (24.7%) cases, intracranial hemorrhage in 33/77 (42.9%) cases and 19/77 (24.7%) patients died. The median time between vaccination and CVT-related headache onset was 8 (interquartile range 7.0-9.7) days. The presence of headache was associated with a higher odd of intracranial hemorrhage (OR 7.4; 95% CI: 2.7-20.8, p < 0.001), but not with death (OR: 0.51, 95% CI: 0.18-1.47, p = 0.213). Conclusion: Delayed onset of headache following an adenovirus vector-based COVID-19 vaccine is associated with development of CVT. Patients with new-onset headache, 1 week after vaccination with an adenovirus vector-based vaccine, should receive a thorough clinical evaluation and CVT must be ruled out.en_US
dc.identifier.citationGarcía-Azorín D, Do TP, Gantenbein AR, Hansen JM, Souza MNP, Obermann M, Pohl H, Schankin CJ, Schytz HW, Sinclair A, Schoonman GG, Kristoffersen ES. Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis. J Headache Pain. 2021 Sep 17;22(1):108. doi: 10.1186/s10194-021-01324-5en_US
dc.identifier.doi10.1186/s10194-021-01324-5
dc.identifier.eissn1129-2377
dc.identifier.issn1129-2369
dc.identifier.pmid34535076
dc.identifier.urihttp://hdl.handle.net/20.500.14200/4399
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.urlhttps://link.springer.com/journal/10194en_US
dc.rights© 2021. The Author(s).
dc.source.beginpage108
dc.source.countryEngland
dc.source.endpage
dc.source.issue1
dc.source.journaltitleThe Journal of Headache and Pain
dc.source.volume22
dc.subjectNeurologyen_US
dc.titleDelayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis.en_US
dc.typeArticle
dspace.entity.typePublication
oa.grant.openaccessnaen_US
rioxxterms.versionNAen_US
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