Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis.
Nydahl, Peter Jeitziner, Marie-Madlen Vater, Vanessa Sivarajah, Sayantha Howroyd, Fiona Osterbrink, Jürgen McWilliams, David
Nydahl, Peter
Jeitziner, Marie-Madlen
Vater, Vanessa
Sivarajah, Sayantha
Howroyd, Fiona
Osterbrink, Jürgen
McWilliams, David
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2022-10-27
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
The search led to 13 studies of low-moderate risk of bias including 2,164 patients. Early mobilisation reduced the risk of delirium by 47 % (13 studies, 2,164 patients, low to moderate risk of bias: Odds Ratio 0.53 (95 % Confidence Interval 0.34 till 0.83, p = 0.01), with significant heterogeneity (I2 = 78 %, p < 0.001). Early mobilisation also reduced the duration of delirium by 1.8 days (3 studies, 296 patients, low-moderate risk of bias: Mean difference -1.78 days (95 % Confidence Interval -2.73 till -0.83 days, p < 0.001), heterogeneity 0 % (p = 0.41). Other analyses such as low risk of bias studies, randomised trials, studies published ≥ 2017, high intensity, and mobilisation as stand-alone intervention showed no significant results, with conflicting certainty of evidence and high heterogeneity. meta-regression could not explain heterogeneity.
Citation
Nydahl P, Jeitziner MM, Vater V, Sivarajah S, Howroyd F, McWilliams D, Osterbrink J. Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis. Intensive Crit Care Nurs. 2023 Feb;74:103334. doi: 10.1016/j.iccn.2022.103334. Epub 2022 Oct 27.
Type
Article