Associated illness severity in schizophrenia and diabetes mellitus : a systematic review
Perry, Benjamin Ian Salimkumar, Dhanya Green, Daniel Meakin, Anne Gibson, Andrew Mahajan, Deepali Tahir, Tayyeb Singh, Swaran
Perry, Benjamin Ian
Salimkumar, Dhanya
Green, Daniel
Meakin, Anne
Gibson, Andrew
Mahajan, Deepali
Tahir, Tayyeb
Singh, Swaran
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Affiliation
University of Warwick; Coventry and Warwickshire Partnership NHS Trust; Cardiff and Vale NHS Trust
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Publication date
2017-06-13
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Abstract
Objective
We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors.
Methods
We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st, 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies.
Results
Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results.
Conclusion
Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors’ knowledge, this is the first systematic review conducted to address this question.
Citation
Perry BI, Salimkumar D, Green D, et al. Associated illness severity in schizophrenia and diabetes mellitus: a systematic review. Psychiatry Res. 2017;256:102–110
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Article