Preoperative c-reactive protein-to-albumin ratio and its ability to predict outcomes of pancreatic cancer resection: a systematic review.
Hajibandeh, Shahin Hajibandeh, Shahab Romman, Saleh Parente, Alessandro Laing, Richard W Satyadas, Thomas Subar, Daren Aroori, Somaiah Bhatt, Anand Durkin, Damien
Hajibandeh, Shahin
Hajibandeh, Shahab
Romman, Saleh
Parente, Alessandro
Laing, Richard W
Satyadas, Thomas
Subar, Daren
Aroori, Somaiah
Bhatt, Anand
Durkin, Damien
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2023-07-13
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Abstract
Objectives: To evaluate the ability of the c-reactive protein-to-albumin ratio (CAR) in predicting outcomes in patients undergoing pancreatic cancer resection.
Methods: A systematic search of electronic information sources and bibliographic reference lists was conducted. Survival outcomes and perioperative morbidity were the evaluated outcome parameters.
Results: Eight studies reporting a total of 1056 patients undergoing pancreatic cancer resection were identified. The median cut-off value for CAR was 0.05 (range 0.0003-0.54). Using multivariate analysis, all studies demonstrated that a higher CAR value was an independent and significant predictor of poor overall survival in patients undergoing pancreatic cancer resection. The estimated hazard ratio (HR) ranged from 1.4 to 3.6. Although there was a positive correlation between the reported cut-off values for CAR and HRs for overall survival, it was weak and non-significant (r = 0.36, n = 6, p = 0.480). There was significant between-study heterogeneity.
Conclusions: Preoperative CAR value seems to be an important prognostic score in predicting survival outcomes in patients undergoing pancreatic cancer resection. However, the current evidence does not allow the determination of an optimal cut-off value for CAR, considering the heterogeneous reporting of cut-off values by the available studies and the lack of knowledge of their sensitivity and specificity. Future research is required.
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Hajibandeh S, Hajibandeh S, Romman S, Parente A, Laing RW, Satyadas T, Subar D, Aroori S, Bhatt A, Durkin D, Athwal TS, Roberts KJ. Preoperative C-Reactive Protein-to-Albumin Ratio and Its Ability to Predict Outcomes of Pancreatic Cancer Resection: A Systematic Review. Biomedicines. 2023 Jul 13;11(7):1983. doi: 10.3390/biomedicines11071983.
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