Cerebral venous system and anatomical predisposition to high-altitude headache.
Wilson, Mark H Davagnanam, Indran Holland, Graeme Dattani, Raj S Tamm, Alexander Hirani, Shashivadan P Kolfschoten, Nicky Strycharczuk, Lisa Green, Cathy Thornton, John S
Wilson, Mark H
Davagnanam, Indran
Holland, Graeme
Dattani, Raj S
Tamm, Alexander
Hirani, Shashivadan P
Kolfschoten, Nicky
Strycharczuk, Lisa
Green, Cathy
Thornton, John S
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2013-02-26
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Abstract
Objective: As inspired oxygen availability falls with ascent to altitude, some individuals develop high-altitude headache (HAH). We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur in the context of restricted venous drainage, and is worsened when cerebral compliance is reduced. We explored this hypothesis in 3 studies.
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Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MP, Montgomery H, Imray C; Birmingham Medical Research Expeditionary Society and Caudwell Xtreme Everest Research Group. Cerebral venous system and anatomical predisposition to high-altitude headache. Ann Neurol. 2013 Mar;73(3):381-9. doi: 10.1002/ana.23796. Epub 2013 Feb 26.
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